Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery

Xiong, Lin, Du, Xin, Shi, Bingyang, Bi, Jingxiu, Kleitz, Freddy and Qiao, Shi Zhang (2015) Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery. Journal of Materials Chemistry B, 3 8: 1712-1721. doi:10.1039/c4tb01601g


Author Xiong, Lin
Du, Xin
Shi, Bingyang
Bi, Jingxiu
Kleitz, Freddy
Qiao, Shi Zhang
Title Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery
Journal name Journal of Materials Chemistry B   Check publisher's open access policy
ISSN 2050-750X
2050-7518
Publication date 2015-02-28
Year available 2015
Sub-type Article (original research)
DOI 10.1039/c4tb01601g
Open Access Status Not Open Access
Volume 3
Issue 8
Start page 1712
End page 1721
Total pages 10
Place of publication Cambridge United Kingdom
Publisher RSC Publications
Collection year 2016
Language eng
Abstract Stellate mesoporous silica nanoparticles with special radial pore morphology were easily synthesized using triethanolamine as the base catalyst in a wide range of synthesis conditions. By adjusting the surfactant composition, reaction temperature and time, and reagent ratio, the particle size of the material could be tailored continuously ranging from 50 to 140 nm and the pore size from 2 to 20 nm. By analyzing the effects of different synthesis parameters, it is concluded that the particles are formed following a nucleation-growth mechanism and the reaction kinetics play an important role in determining the particle size and pore structure. These stellate MSNs can be conveniently functionalized with a nontoxic low molecular weight poly(ethylene imine) (PEI, 800 Da) by a delayed condensation method. The resulting nanocomposites not only possess auto-fluorescence for suitable particle tracking but also demonstrate good potential for intracellular delivery of the anticancer doxorubicin drug.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
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