Oxyntomodulin regulates resetting of the liver circadian clock by food

Landgraf, Dominic, Tsang, Anthony H., Leliavski, Alexei, Koch, Christiane E., Barclay, Johanna L., Drucker, Daniel J. and Oster, Henrik (2015) Oxyntomodulin regulates resetting of the liver circadian clock by food. eLife, 4 e06253: 1-16. doi:10.7554/eLife.06253


Author Landgraf, Dominic
Tsang, Anthony H.
Leliavski, Alexei
Koch, Christiane E.
Barclay, Johanna L.
Drucker, Daniel J.
Oster, Henrik
Title Oxyntomodulin regulates resetting of the liver circadian clock by food
Journal name eLife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2015-03-30
Year available 2015
Sub-type Article (original research)
DOI 10.7554/eLife.06253
Open Access Status DOI
Volume 4
Issue e06253
Start page 1
End page 16
Total pages 16
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Collection year 2016
Language eng
Formatted abstract
Circadian clocks coordinate 24-hr rhythms of behavior and physiology. In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light–dark cycle, while timed food intake is a potent synchronizer of peripheral clocks such as the liver. Alterations in food intake rhythms can uncouple peripheral clocks from the SCN, resulting in internal desynchrony, which promotes obesity and metabolic disorders. Pancreas-derived hormones such as insulin and glucagon have been implicated in signaling mealtime to peripheral clocks. In this study, we identify a novel, more direct pathway of food-driven liver clock resetting involving oxyntomodulin (OXM). In mice, food intake stimulates OXM secretion from the gut, which resets liver transcription rhythms via induction of the core clock genes Per1 and 2. Inhibition of OXM signaling blocks food-mediated resetting of hepatocyte clocks. These data reveal a direct link between gastric filling with food and circadian rhythm phasing in metabolic tissues.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Non HERDC
 
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Created: Wed, 17 Jun 2015, 14:47:52 EST by Johanna Barclay on behalf of Mater Research Institute-UQ