Spatiotemporal Scan and Age-Period-Cohort Analysis of Hepatitis C Virus in Henan, China: 2005–2012

Chen, Fangfang, Sun, Dingyong, Guo, Yuming, Guo, Wei, Ding, Zhengwei, Li, Peilong, Li, Jie, Ge, Lin, Li, Ning, Li, Dongmin, Wang, Zhe and Wang, Lu (2015) Spatiotemporal Scan and Age-Period-Cohort Analysis of Hepatitis C Virus in Henan, China: 2005–2012. PLoS One, 10 6: . doi:10.1371/journal.pone.0129746

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Author Chen, Fangfang
Sun, Dingyong
Guo, Yuming
Guo, Wei
Ding, Zhengwei
Li, Peilong
Li, Jie
Ge, Lin
Li, Ning
Li, Dongmin
Wang, Zhe
Wang, Lu
Title Spatiotemporal Scan and Age-Period-Cohort Analysis of Hepatitis C Virus in Henan, China: 2005–2012
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-06-15
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0129746
Open Access Status DOI
Volume 10
Issue 6
Total pages 14
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2016
Language eng
Formatted abstract
Studies have shown that hepatitis C virus (HCV) infection increased during the past decades in China. However, little evidence is available on when, where, and who were infected with HCV. There are gaps in knowledge on the epidemiological burden and evolution of the HCV epidemic in China.

Data on HCV cases were collected by the disease surveillance system from 2005 to 2012 to explore the epidemic in Henan province. Spatiotemporal scan statistics and age-period-cohort (APC) model were used to examine the effects of age, period, birth cohort, and spatiotemporal clustering.

177,171 HCV cases were reported in Henan province between 2005 and 2012. APC modelling showed that the HCV reported rates significantly increased in people aged > 50 years. A moderate increase in HCV reported rates was observed for females aged about 25 years. HCV reported rates increased over the study period. Infection rates were greatest among people born between 1960 and 1980. People born around 1970 had the highest relative risk of HCV infection. Women born between 1960 and 1980 had a five-fold increase in HCV infection rates compared to men, for the same birth cohort. Spatiotemporal mapping showed major clustering of cases in northern Henan, which probably evolved much earlier than other areas in the province.

Spatiotemporal mapping and APC methods are useful to help delineate the evolution of the HCV epidemic. Birth cohort should be part of the criteria screening programmes for HCV in order to identify those at highest risk of infection and unaware of their status. As Henan is unique in the transmission route for HCV, these methods should be used in other high burden provinces to help identify subpopulations at risk.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
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Created: Wed, 17 Jun 2015, 14:18:53 EST by Yuming Guo on behalf of School of Public Health