CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015) CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. BMJ, 350 . doi:10.1136/bmj.h1793

Author Shamseer, Larissa
Sampson, Margaret
Bukutu, Cecilia
Schmid, Christopher H.
Nikles, Jane
Tate, Robyn
Johnston, Bradley C.
Zucker, Deborah
Shadish, William R.
Kravitz, Richard
Guyatt, Gordon
Altman, Douglas G.
Moher, David
Vohra, Sunita
the CENT group
Title CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration
Journal name BMJ
ISSN 0959-535X
Publication date 2015-05
Year available 2015
Sub-type Article (original research)
DOI 10.1136/bmj.h1793
Open Access Status DOI
Volume 350
Total pages 30
Place of publication London, United Kingdom
Publisher B M J Group [Elsevier]
Collection year 2016
Language eng
Formatted abstract
N-of-1 trials are a useful tool for clinicians who want to determine the effectiveness of a treatment in a particular individual. The reporting of N-of-1 trials has been variable and incomplete, hindering their usefulness in clinical decision making and by future researchers. This document presents the CONSORT (Consolidated Standards of Reporting Trials) extension for N-of-1 trials (CENT 2015). CENT 2015 extends the CONSORT 2010 guidance to facilitate the preparation and appraisal of reports of an individual N-of-1 trial or a series of prospectively planned, multiple, crossover N-of-1 trials. CENT 2015 elaborates on 14 items of the CONSORT 2010 checklist, totalling 25 checklist items (44 sub-items), and recommends diagrams to help authors document the progress of one participant through a trial or more than one participant through a trial or series of trials, as applicable. Examples of good reporting and evidence based rationale for CENT 2015 checklist items are provided.
Keyword Randomized Controlled Trials
Single Case Research
Clinical Trial
Herbal Interventions
Individual Patients
Crossover Trials
General Practice
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Discipline of General Practice Publications
Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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