CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015) CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 350 . doi:10.1136/bmj.h1738


Author Vohra, Sunita
Shamseer, Larissa
Sampson, Margaret
Bukutu, Cecilia
Schmid, Christopher H.
Tate, Robyn
Nikles, Jane
Zucker, Deborah R.
Kravitz, Richard
Guyatt, Gordon
Altman, Douglas G.
Moher, David
the CENT group
Title CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement
Journal name BMJ
ISSN 0959-535X
1756-1833
Publication date 2015-05
Year available 2015
Sub-type Article (original research)
DOI 10.1136/bmj.h1738
Open Access Status DOI
Volume 350
Total pages 7
Place of publication London, United Kingdom
Publisher B M J Group [Elsevier]
Collection year 2016
Language eng
Formatted abstract
N-of-1 trials provide a mechanism for making evidence based treatment decisions for an individual patient.  They use key methodological elements of group clinical trials to evaluate treatment effectiveness in a single patient, for situations that
cannot always accommodate large scale trials: rare diseases, comorbid conditions, or in patients using concurrent therapies. Improvement in the reporting and clarity of methods and findings in N-of-1 trials is essential for reader to gauge the validity of trials and to replicate successful findings. A CONSORT extension for N-of-1 trials (CENT 2015) provides guidance on the
reporting of individual and series of N-of-1 trials. CENT provides additional guidance for 14 of the 25 items of the CONSORT 2010 checklist and recommends a diagram for depicting an individual N-of-1 trial and modifies the CONSORT flow diagram to address the flow of a series of N-of-1 trials. The rationale, development process, and CENT 2015 checklist and diagrams are reported in this document.
Keyword Randomized Controlled Trials
Quality
Interventions
Elaboration
Explanation
Designs
Scale
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Discipline of General Practice Publications
Official 2016 Collection
School of Medicine Publications
 
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