Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes

Yang, Sundy N. Y., Burch, Micah L., Tannock, Lisa R., Evanko, Stephen, Osman, Narin and Little, Peter J. (2010) Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes. Journal of Diabetes, 2 4: 233-242. doi:10.1111/j.1753-0407.2010.00089.x


Author Yang, Sundy N. Y.
Burch, Micah L.
Tannock, Lisa R.
Evanko, Stephen
Osman, Narin
Little, Peter J.
Title Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes
Journal name Journal of Diabetes   Check publisher's open access policy
ISSN 1753-0393
1753-0407
Publication date 2010-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1753-0407.2010.00089.x
Open Access Status Not Open Access
Volume 2
Issue 4
Start page 233
End page 242
Total pages 10
Place of publication Hoboken, NJ United States
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Atherosclerosis is accelerated in the setting of diabetes, but the factors driving this phenomenon remain elusive. Hyperglycemia leads to elevated levels of transforming growth factor (TGF)-β and TGF-β has been implicated as a factor in atherosclerosis. Given the established association between hyperglycemia and elevated TGF-β, it is plausible that elevated TGF-β levels in diabetes play a pathogenic role in the development of accelerated atherosclerosis. TGF-β is a potent regulator of extracellular matrix synthesis, including many actions on proteoglycan synthesis that lead to increased binding to low-density lipoprotein and therefore potentially increased lipid retention in the vessel wall and accelerated atherosclerosis. TGF-β signals through the canonical TGF-β receptor I-mediated phosphorylation of Smad transcription factors and TGF-β signaling is also known to involve, positively and negatively, interactions with the mitogen-activated protein kinase pathways. The focus of the present review is on the effects of TGF-β on proteoglycan synthesis in vascular smooth muscle and particularly the signaling pathways through which TGF-β exerts its effects, because those pathways may be therapeutic targets for the prevention of pathological modifications in the proteoglycan component of the vessel wall in the vascular diseases of diabetes.
Keyword Macrovascular disease
Response to retention
Smads
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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