Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins

Yang, Sundy N. Y., Osman, Narin, Burch, Micah L. and Little, Peter J. (2009) Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins. Future Lipidology, 4 4: 479-492. doi:10.2217/CLP.09.37


Author Yang, Sundy N. Y.
Osman, Narin
Burch, Micah L.
Little, Peter J.
Title Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins
Journal name Future Lipidology   Check publisher's open access policy
ISSN 1746-0875
1758-4302
Publication date 2009-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/CLP.09.37
Open Access Status Not yet assessed
Volume 4
Issue 4
Start page 479
End page 492
Total pages 14
Place of publication London, United Kingdom
Publisher Future Medicine
Language eng
Abstract Atherosclerosis and its sequelae remain the major contributors to morbidity and premature mortality, despite the availability of the efficacious statin drugs. It has recently been demonstrated that human atherosclerosis in coronary arteries commences with the binding and retention of atherogenic ApoB-containing lipoproteins by modified proteoglycans. Vascular smooth muscle cells are the major source of proteoglycans in the vessel wall. A multitude of vasoactive factors stimulate the synthesis of proteoglycans and modify the structure of glycosaminoglycan chains produced by vascular smooth muscle cells and numerous diabetes and cardiovascular drugs prevent or reverse changes in proteoglycan synthesis. This review considers these factors and the extent to which they modify the interaction of proteoglycans with lipids and, thus, drive or delay the development of atherosclerosis.
Keyword Atherosclerosis
Cardiovascular dru
LDL
Proteoglcan
Response to retention
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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