Forkhead family transcription factor FoxO and neural differentiation

Wen, Qiang, Wang, Haitao, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2012) Forkhead family transcription factor FoxO and neural differentiation. Neurogenetics, 13 2: 105-113. doi:10.1007/s10048-012-0320-2


Author Wen, Qiang
Wang, Haitao
Little, Peter J.
Quirion, Remi
Zheng, Wenhua
Title Forkhead family transcription factor FoxO and neural differentiation
Journal name Neurogenetics   Check publisher's open access policy
ISSN 1364-6745
1364-6753
Publication date 2012-05
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s10048-012-0320-2
Open Access Status Not yet assessed
Volume 13
Issue 2
Start page 105
End page 113
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract The Forkhead Box subgroup O (FoxO) transcription factor family is one of the most important downstream targets of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway playing an important role in many biological functions including transcriptional regulation of cellular differentiation. Neuronal differentiation is a complex process which involves many signaling pathways and molecular mechanisms. Interestingly, recent studies indicate that the FoxO family is involved in a number of signaling pathways regulating cell differentiation. The actions occur at different stages in the differentiation process and by differing mechanisms. This review will focus on FoxO as a novel transcription factor in neural differentiation.
Keyword Cellular signaling
FoxO
Neural differentiation
PI3K/Akt
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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