Emerging lipoprotein-related therapeutics for patients with diabetes

Little, Peter J., Chait, Alan, Januszewski, Andrzej S., Bobik, Alex, O'Neal, David and Jenkins, Alicia J. (2014). Emerging lipoprotein-related therapeutics for patients with diabetes. In Alicia J. Jenkins, Peter P. Toth and Timothy J. Lyons (Ed.), Lipoproteins in diabetes mellitus (pp. 435-453) New York, United States: Springer. doi:10.1007/978-1-4614-7554-5_23

Author Little, Peter J.
Chait, Alan
Januszewski, Andrzej S.
Bobik, Alex
O'Neal, David
Jenkins, Alicia J.
Title of chapter Emerging lipoprotein-related therapeutics for patients with diabetes
Title of book Lipoproteins in diabetes mellitus
Place of Publication New York, United States
Publisher Springer
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4614-7554-5_23
Open Access Status Not yet assessed
Series Contemporary Diabetes
ISBN 9781461475538
ISSN 2197-7836
Editor Alicia J. Jenkins
Peter P. Toth
Timothy J. Lyons
Chapter number 23
Start page 435
End page 453
Total pages 19
Total chapters 23
Language eng
Abstract/Summary Dyslipidemia is a major risk factor for atherosclerosis in both diabetic and nondiabetic subjects, which is a common cause of morbidity and premature mortality. Based on and supported by favorable outcomes of clinical trials, drugs targeting lipoprotein metabolism are widely used, particularly in developed countries. Drugs to improve lipid levels, in particular to lower low-density lipoprotein (LDL) cholesterol (LDL-C), are commonly used for the primary and secondary prevention of cardiovascular disease. Of the LDL-C-lowering drugs, HMG-CoA reductase inhibitors (“statins”) are particularly effective at reducing cardiovascular disease, both in people with and without diabetes mellitus [1, 2], with more intensive LDL-C lowering being more effective than less intensive LDL-C lowering [3–12]. Statins are effective cardioprotective agents in both type 1 and type 2 diabetes patients [2].
Keyword High density lipoprotein
Coronary heart disease
Randomized controlled-trial
Ester-transfer protein
I mimetic peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: School of Pharmacy Publications
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