Cardiovascular actions and therapeutic potential of tanshinone IIA

Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing and Xu, Suowen (2012) Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis, 220 1: 3-10. doi:10.1016/j.atherosclerosis.2011.06.041


Author Gao, Si
Liu, Zhiping
Li, Hong
Little, Peter J.
Liu, Peiqing
Xu, Suowen
Title Cardiovascular actions and therapeutic potential of tanshinone IIA
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2012
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.atherosclerosis.2011.06.041
Open Access Status
Volume 220
Issue 1
Start page 3
End page 10
Total pages 8
Place of publication Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian countries for the prevention and treatment of coronary heart disease. Recently, the pharmacological properties of TS in the cardiovascular system have attracted great interest. Emerging experimental studies and clinical trials have demonstrated that TS prevents atherogenesis as well as cardiac injury and hypertrophy. In atherosclerosis, TS acts by inhibiting LDL oxidation, monocyte adhesion to endothelium, smooth muscle cell migration and proliferation, macrophage cholesterol accumulation, proinflammatory cytokine expression and platelet aggregation. TS has some activity and potential to stabilize atherosclerotic plaques. The cardioprotective effects of TS are mainly related to its anti-oxidant and anti-inflammatory actions. In this review, we focus on the protective effects and the mechanism of action of TS in the cardiovascular system, and provide a novel perspective on clinical use of TS.
Keyword Anti-oxidant
Atherosclerosis
Cardiac hypertrophy
Myocardial infarction
Oxidized LDL
Tanshinone IIA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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