Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse

Okutsu, Mitsuharu, Lira, Vitor A., Higashida, Kazuhiko, Peake, Jonathan, Higuchi, Mitsuru and Suzuki, Katsuhiko (2014) Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis, 232 2: 414-419. doi:10.1016/j.atherosclerosis.2013.11.076

Author Okutsu, Mitsuharu
Lira, Vitor A.
Higashida, Kazuhiko
Peake, Jonathan
Higuchi, Mitsuru
Suzuki, Katsuhiko
Title Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
Publication date 2014-02
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2013.11.076
Open Access Status Not Open Access
Volume 232
Issue 2
Start page 414
End page 419
Total pages 6
Place of publication Shannon, Clare Ireland
Publisher Elsevier
Language eng
Formatted abstract
Chronic stress is an important risk factor for atherosclerosis, which is a chief process in the development of cardiovascular disease. Increased circulating levels of corticosterone have been documented in several animal models of chronic stress. However, it remains to be established whether corticosterone is sufficient to exacerbate atherosclerosis. To test this hypothesis, apolipoprotein E (ApoE)-deficient mice were fed a high-fat diet for 13 weeks with exposure to either corticosterone or vehicle in the drinking water (CORT and Con). Corticosterone treatment significantly increased atherosclerotic plaque area at the aortic root. Such exacerbation of atherosclerosis was accompanied by significantly lower levels of circulating white blood cells and serum interleukin-1β (IL-1β), and significantly elevated serum concentrations of total cholesterol, low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and small dense low-density lipoprotein (sd-LDL) in CORT mice when compared to Con mice. These findings demonstrate that corticosterone is sufficient to exacerbate atherosclerosis in vivo despite its anti-inflammatory properties and that this marked pro-atherogenic phenotype is primarily associated with increased dyslipidaemia.
Keyword Stress
Hypothalamic-pituitary-adrenal axis
ApoE-deficient mice
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
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