Preparation and characterization of carbon nanotube-grafted-chitosan - natural hydroxyapatite composite for bone tissue engineering

Venkatesan, Jayachandran, Qian, Zhong-Ji, Ryu, BoMi, Kumar, Nanjundan Ashok and Kim, Se-Kwon (2011) Preparation and characterization of carbon nanotube-grafted-chitosan - natural hydroxyapatite composite for bone tissue engineering. Carbohydrate Polymers, 83 2: 569-577. doi:10.1016/j.carbpol.2010.08.019


Author Venkatesan, Jayachandran
Qian, Zhong-Ji
Ryu, BoMi
Kumar, Nanjundan Ashok
Kim, Se-Kwon
Title Preparation and characterization of carbon nanotube-grafted-chitosan - natural hydroxyapatite composite for bone tissue engineering
Journal name Carbohydrate Polymers   Check publisher's open access policy
ISSN 0144-8617
1879-1344
Publication date 2011-01-10
Sub-type Article (original research)
DOI 10.1016/j.carbpol.2010.08.019
Open Access Status Not yet assessed
Volume 83
Issue 2
Start page 569
End page 577
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Formatted abstract
Porous, biodegradable and biocompatible chitosan, chitosan with natural hydroxyapatite derived from Thunnus Obesus bone (chitosan/HAp) and chitosan grafted with functionalized multiwalled carbon nanotube in addition to HAp (f-MWCNT-g-chitosan/HAp) scaffolds were prepared for the first time via freeze-drying method and physiochemically characterized as bone graft substitutes. The cross-linkages in the novel f-MWCNT-g-chitosan/HAp scaffold were observed by FT-IR spectroscopy. The water uptake, retention ability and degradation of composite scaffolds decreased whereas thermal stability increased with an addition of HAp and f-MWCNT. Uniform dispersion of HAp and f-MWCNT in chitosan matrix with interconnected porosity of 70-200 μm (chitosan/HAp) and 46-200 μm (f-MWCNT-g-chitosan/HAp) was observed by X-ray diffraction, scanning electron microscopy and optical microscopy. Cell proliferation in composite scaffolds was twice than in pure chitosan when checked in vitro using MG-63 cell line. These observations suggest that the novel chitosan/HAp and f-MWCNT-g-chitosan/HAp composite scaffolds are promising biomaterials for bone tissue engineering.
Keyword Bone tissue engineering
Chitosan
Functionalized multiwalled carbon nanotube
Hydroxyapatite
Scaffolds
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemical Engineering Publications
 
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