The origin of the mammalian kidney: Implications for recreating the kidney in vitro

Takasato, Minoru and Little, Melissa H (2015) The origin of the mammalian kidney: Implications for recreating the kidney in vitro. Development (Cambridge), 142 11: 1937-1947. doi:10.1242/dev.104802

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Author Takasato, Minoru
Little, Melissa H
Title The origin of the mammalian kidney: Implications for recreating the kidney in vitro
Journal name Development (Cambridge)   Check publisher's open access policy
ISSN 1477-9129
Publication date 2015-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1242/dev.104802
Open Access Status File (Publisher version)
Volume 142
Issue 11
Start page 1937
End page 1947
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Collection year 2016
Language eng
Abstract The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme (MM), which forms the rest of the kidney, derive from the IM. Based on an understanding of the signalling molecules crucial for IM patterning and kidney morphogenesis, several studies have now generated UB or MM, or both, in vitro via the directed differentiation of human pluripotent stem cells. Although these results support the IM origin of the UB and the MM, they challenge the simplistic view of a common progenitor for these two populations, prompting a reanalysis of early patterning events within the IM. Here, we review our understanding of the origin of the UB and the MM in mouse, and discuss how this impacts on kidney regeneration strategies and furthers our understanding of human development.
Keyword Kidney development
Directed differentiation
Nephrogenic mesenchyme
Pluripotent stem cell
Ureteric bud
Stem cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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