Hepcidin: Regulation of the master iron regulator

Rishi, Gautam, Wallace, Daniel F. and Subramaniam, V. Nathan (2015) Hepcidin: Regulation of the master iron regulator. Bioscience Reports, 35 3: e00192-e00192. doi:10.1042/BSR20150014

Author Rishi, Gautam
Wallace, Daniel F.
Subramaniam, V. Nathan
Title Hepcidin: Regulation of the master iron regulator
Journal name Bioscience Reports   Check publisher's open access policy
ISSN 0144-8463
Publication date 2015
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1042/BSR20150014
Open Access Status DOI
Volume 35
Issue 3
Start page e00192
End page e00192
Total pages 12
Place of publication London, United Kingdom
Publisher Portland Press
Collection year 2016
Language eng
Formatted abstract
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a defined pathway to excrete excess iron makes it essential for the body to regulate the amount of iron absorbed; a deficiency could lead to iron deficiency and an excess to iron overload and associated disorders such as anaemia and haemochromatosis respectively. This regulation is mediated by the iron-regulatory hormone hepcidin. Hepcidin binds to the only known iron export protein, ferroportin (FPN), inducing its internalization and degradation, thus limiting the amount of iron released into the blood. The major factors that are implicated in hepcidin regulation include iron stores, hypoxia, inflammation and erythropoiesis. The present review summarizes our present knowledge about the molecular mechanisms and signalling pathways contributing to hepcidin regulation by these factors.
Keyword Erythropoiesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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