Dysplastic nevus: Fact and fiction

Rosendahl, Cliff O., Grant-Kels, Jane M. and Que, Syril Keena T. (2015) Dysplastic nevus: Fact and fiction. Journal of the American Academy of Dermatology, 73 3: 507-512. doi:10.1016/j.jaad.2015.04.029


Author Rosendahl, Cliff O.
Grant-Kels, Jane M.
Que, Syril Keena T.
Title Dysplastic nevus: Fact and fiction
Journal name Journal of the American Academy of Dermatology   Check publisher's open access policy
ISSN 1097-6787
0190-9622
Publication date 2015-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jaad.2015.04.029
Open Access Status Not yet assessed
Volume 73
Issue 3
Start page 507
End page 512
Total pages 6
Place of publication Philadelphia, United States
Publisher Mosby
Collection year 2016
Language eng
Subject 2708 Dermatology
Abstract The term “dysplastic nevus” (DN) implies that this nevus exists as a distinct and defined entity of potential detriment to its host. We examine the current data, which suggest that this entity exists as histologically and possibly genetically different from common nevus, with some overlapping features. Studies show that a melanoma associated with a nevus is just as likely to arise in a common nevus as in DN. Furthermore, there is no evidence that a histologically defined DN evolves into a melanoma or that the presence of 1 or more DN on an individual patient confers any increased melanoma risk. We suggest that the term “dysplastic nevus” be abandoned so that the focus can shift to confirmed and relevant indicators of melanoma risk, including high nevus counts and large nevus size.
Keyword B-K mole syndrome
BRAF
Common nevus
Congenital melanocytic nevus
Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Dysplastic nevus
Familial atypical multiple-mole melanoma
Melanoma
P16, p53
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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