Recurrent myocardial infarction secondary to Prinzmetal’s variant angina

Murdoch, Dale, Dhillon, Priyanka and Niranjan, Selvanayagam (2015) Recurrent myocardial infarction secondary to Prinzmetal’s variant angina. Singapore Medical Journal, 56 5: e74-e77. doi:10.11622/smedj.2015077

Author Murdoch, Dale
Dhillon, Priyanka
Niranjan, Selvanayagam
Title Recurrent myocardial infarction secondary to Prinzmetal’s variant angina
Journal name Singapore Medical Journal   Check publisher's open access policy
ISSN 0037-5675
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.11622/smedj.2015077
Open Access Status DOI
Volume 56
Issue 5
Start page e74
End page e77
Total pages 4
Place of publication Singapore
Publisher Singapore Medical Association
Collection year 2016
Language eng
Subject 2700 Medicine
Abstract Prinzmetal’s variant angina describes chest pain secondary to reversible coronary artery vasospasm in the context of both diseased and non-diseased coronary arteries. Symptoms typically occur when the patient is at rest and are associated with transient ST-segment elevation. Acute episodes respond to glyceryl trinitrate, but myocardial infarction and other potentially fatal complications can occur, and long-term management can be challenging. Although it is not well understood, the underlying mechanism appears to involve a combination of endothelial damage and vasoactive mediators. In this case, a 35-year-old woman with myocardial infarction secondary to coronary artery vasospasm experienced recurrent chest pain. Coronary angiography revealed severe focal stenosis in the mid left anterior descending artery, which completely resolved after administration of intracoronary glyceryl trinitrate. The patient was discharged on nitrates and calcium channel blockers. The patient re-presented with another myocardial infarction, requiring up-titration of medical therapy.
Keyword Coronary artery spasm
Myocardial infarction
Prinzmetal’s variant angina
Vasospastic angina
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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