Muscular strength, aerobic capacity, and adipocytokines in obese youth after resistance training: A pilot study

Shultz, Sarah P, Dahiya, Rachana, Leong, Gary M, Rowlands, David S, Hills, Andrew Hills and Byrne, Nuala M (2015) Muscular strength, aerobic capacity, and adipocytokines in obese youth after resistance training: A pilot study. Australasian Medical Journal, 8 4: 113-120. doi:10.4066/AMJ.2015.2293

Author Shultz, Sarah P
Dahiya, Rachana
Leong, Gary M
Rowlands, David S
Hills, Andrew Hills
Byrne, Nuala M
Title Muscular strength, aerobic capacity, and adipocytokines in obese youth after resistance training: A pilot study
Journal name Australasian Medical Journal   Check publisher's open access policy
ISSN 1836-1935
Publication date 2015-04-30
Year available 2015
Sub-type Article (original research)
DOI 10.4066/AMJ.2015.2293
Open Access Status DOI
Volume 8
Issue 4
Start page 113
End page 120
Total pages 8
Place of publication Perth, Australia
Publisher Australasian Medical Journal Pty Ltd
Collection year 2016
Language eng
Formatted abstract

Exercise has shown positive training effects on obesity-related inflammation, however, resistance training has shown mixed results concerning adipocytokine levels.


The purpose of this pilot study was to explore the effects of resistance training on blood adipocytokine concentrations in obese youth, with specific examination of the relationship between these biomarkers and improved fitness (i.e., aerobic capacity, muscular strength).


Fourteen obese adolescents (16.1 ±1.6 y; BMI: 32.3 ±3.9 kg/m2) participated in a 16-week resistance training intervention. Body composition, fasting blood concentrations of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-ɑ), adiponectin, and leptin were measured pre- and post-training. Aerobic capacity was assessed via a maximal discontinuous exercise test. The rate of gain in muscular strength was calculated as the slope of progression in 1-repetition maximum throughout the intervention.


Resistance training increased lean mass (total, trunk) and decreased per cent body fat (total, trunk). The training also caused moderate clear decreases in IL-6 and TNF-ɑ concentrations. A small increase in adiponectin was also observed before and after intervention. When the group was stratified by changes in aerobic capacity, there were substantially larger decreases in leptin levels for those with improved capacity. Correlation analyses also revealed a negative relationship between log-transformed leptin and aerobic capacity at rest. Improvement in quadriceps strength was positively correlated with IL-6 and TNF-ɑ, while improvement in shoulder adductor strength was positively correlated with IL-6 only.


Resistance training improved adipocytokine markers, which were partially associated with improved physical fitness. Specifically, the relationship between strength improvements and IL-6 and TNF-ɑ suggests an exercise-induced signalling pathway that results in overall adaptive decreases in systemic inflammation in obese youth.
Keyword Exercise
Paediatric obesity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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