Influence of sampling site on uterine artery Doppler indices at 11-13+6 weeks gestation

Ridding, G., Schluter, P. J., Hyett, J. A. and McLennan, A. C. (2015) Influence of sampling site on uterine artery Doppler indices at 11-13+6 weeks gestation. Fetal Diagnosis and Therapy, 37 4: 310-315. doi:10.1159/000366060


Author Ridding, G.
Schluter, P. J.
Hyett, J. A.
McLennan, A. C.
Title Influence of sampling site on uterine artery Doppler indices at 11-13+6 weeks gestation
Formatted title
Influence of sampling site on uterine artery Doppler indices at 11-13+6 weeks gestation
Journal name Fetal Diagnosis and Therapy   Check publisher's open access policy
ISSN 1421-9964
1015-3837
Publication date 2015-05-28
Sub-type Article (original research)
DOI 10.1159/000366060
Open Access Status Not yet assessed
Volume 37
Issue 4
Start page 310
End page 315
Total pages 6
Place of publication Basel, Switzerland
Publisher S. Karger AG
Collection year 2016
Language eng
Formatted abstract
Introduction: Uterine artery pulsatility index (PI) is a key variable in the first trimester screening for pre-eclampsia. The aims of the study were to examine the effect of sampling the uterine arteries at a site distal to the level of the internal os, and to determine a lower limit of peak systolic velocity (PSV) to establish an auditable standard.

Material and Methods: PI and PSV measurements were performed at 11-13+6 weeks' gestation at two sites: at the level of the internal os and 3 cm distal to the internal os. Comparative analyses utilised the Student's paired t-test. A 90% reference interval of transformed PSV measurements at the internal os was generated by polynomial regression.

Results: There was a significant reduction in both the PI (14.9%) and the PSV (17.4%) when measured at the distal site compared to the level of the internal os (both p < 0.001). The best estimated 5th centile for uterine artery PSV at 11-13+6 weeks was 60.9 cm/s.

Conclusion: PI measurements performed distal to the internal os are significantly lower and will result in inaccurate pre-eclampsia risk assessment. PSV measurements below 60 cm/s are likely to indicate an incorrect sampling site. Development of auditable measurement standards is important to ensure accuracy of prospective pre-eclampsia screening.
Keyword Doppler
First trimester
Internal os
Pre-eclampsia
Ultrasound
Uterine artery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Nursing, Midwifery and Social Work Publications
 
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