Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis

McCombe, P. A., Pfluger, C., Singh, P., Lim, C. Y. H., Airey, C. and Henderson, R. D. (2015) Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 353 1-2: 122-129. doi:10.1016/j.jns.2015.04.032

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Author McCombe, P. A.
Pfluger, C.
Singh, P.
Lim, C. Y. H.
Airey, C.
Henderson, R. D.
Title Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
ISSN 1878-5883
0022-510X
Publication date 2015-06-15
Sub-type Article (original research)
DOI 10.1016/j.jns.2015.04.032
Open Access Status DOI
Volume 353
Issue 1-2
Start page 122
End page 129
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract There is a need for a blood biomarker of disease activity in ALS. This marker needs to measure the loss of motor neurones. Phosphorylated neurofilament heavy chain (pNfH) in the serum is a biomarker of axonal injury. Previous studies have found that levels of pNfH are elevated in ALS. We have performed a serial study of pNfH levels in 98 subjects from our ALS clinic. There was significant elevation of levels of pNfH in subjects with ALS compared to controls, although there was considerable variability. In studies of individuals who had two or more serial samples, we found that the levels of pNfH increased over time in the early stage of disease. Levels were low in subjects with long survival. The rate of rise of pNfH was inversely correlated with survival. We suggest that the initial level of pNfH is a marker of disease severity and that changes in pNfH levels are markers of disease progression.
Keyword Amyotrophic lateral sclerosis
Biomarkers
Motor neurone disease
Neurofilament
Prognosis
Survival
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
 
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