Traditional serrated adenoma: An update

Bettington, Mark L and Chetty, Runjan (2015) Traditional serrated adenoma: An update. Human Pathology, 46 7: 933-938. doi:10.1016/j.humpath.2015.04.002

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ362511_OA.pdf Full text (open access) application/pdf 1.09MB 1

Author Bettington, Mark L
Chetty, Runjan
Title Traditional serrated adenoma: An update
Journal name Human Pathology   Check publisher's open access policy
ISSN 1532-8392
Publication date 2015-07
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.humpath.2015.04.002
Open Access Status File (Author Post-print)
Volume 46
Issue 7
Start page 933
End page 938
Total pages 6
Place of publication Maryland Heights, United States
Publisher W.B. Saunders
Collection year 2016
Language eng
Formatted abstract
Although recognized 25 years ago, the traditional serrated adenoma (TSA) remains an ongoing source of diagnostic and biologic debate. Recent research has greatly improved our understanding of the morphological and molecular aspects of these polyps. In particular, the recognition of ectopic crypt foci (ECFs) in combination with typical cytology and slitlike serrations improves diagnostic reproducibility. Awareness that many TSAs, particularly BRAF-mutated TSAs, arise in precursor microvesicular hyperplastic polyps and sessile serrated adenomas can aid in making this diagnosis and should not be confused with a sessile serrated adenoma with dysplasia. At a molecular level, TSAs can be divided into 2 groups based on their BRAF or KRAS mutation status. The development of overt cytologic dysplasia is accompanied by TP53 mutation, Wnt pathway activation, and, in some cases, silencing of CDKN2A. Importantly, however, mismatch repair enzyme function is retained. Thus, the TSA is an important precursor of aggressive molecular subtypes of colorectal carcinoma.
Keyword Serrated polyp
Traditional serrated adenoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 09 Jun 2015, 00:46:06 EST by System User on behalf of Scholarly Communication and Digitisation Service