Urinary tract infection of mice to model human disease: Practicalities, implications and limitations

Carey, Alison J., Tan, Chee K., Ipe, Deepak S., Sullivan, Matthew J., Cripps, Allan W., Schembri, Mark A. and Ulett, Glen C. (2015) Urinary tract infection of mice to model human disease: Practicalities, implications and limitations. Critical Reviews in Microbiology, 42 5: 780-799. doi:10.3109/1040841X.2015.1028885


Author Carey, Alison J.
Tan, Chee K.
Ipe, Deepak S.
Sullivan, Matthew J.
Cripps, Allan W.
Schembri, Mark A.
Ulett, Glen C.
Title Urinary tract infection of mice to model human disease: Practicalities, implications and limitations
Journal name Critical Reviews in Microbiology   Check publisher's open access policy
ISSN 1040-841X
1549-7828
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.3109/1040841X.2015.1028885
Open Access Status Not Open Access
Volume 42
Issue 5
Start page 780
End page 799
Total pages 20
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2016
Language eng
Formatted abstract
Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Murine models of human UTI are vital experimental tools that have helped to elucidate UTI pathogenesis and advance knowledge of potential treatment and infection prevention strategies. Fundamentally, several variables are inherent in different murine models, and understanding the limitations of these variables provides an opportunity to understand how models may be best applied to research aimed at mimicking human disease. In this review, we discuss variables inherent in murine UTI model studies and how these affect model usage, data analysis and data interpretation. We examine recent studies that have elucidated UTI host–pathogen interactions from the perspective of gene expression, and review new studies of biofilm and UTI preventative approaches. We also consider potential standards for variables inherent in murine UTI models and discuss how these might expand the utility of models for mimicking human disease and uncovering new aspects of pathogenesis.

Keyword Animal Models
Bacterial Pathogenesis
Escherichia coli
Innate Immunity
Urinary tract infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 05 Jun 2015, 09:51:04 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences