Age-related differences in corticomotor facilitation indicate dedifferentiation in motor planning

Reuter, Eva-Maria, Behrens, Martin and Zschorlich, Volker R. (2015) Age-related differences in corticomotor facilitation indicate dedifferentiation in motor planning. Experimental Gerontology, 65 79-84. doi:10.1016/j.exger.2015.03.008


Author Reuter, Eva-Maria
Behrens, Martin
Zschorlich, Volker R.
Title Age-related differences in corticomotor facilitation indicate dedifferentiation in motor planning
Journal name Experimental Gerontology   Check publisher's open access policy
ISSN 1873-6815
0531-5565
Publication date 2015-05-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.exger.2015.03.008
Open Access Status
Volume 65
Start page 79
End page 84
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Elsevier
Collection year 2016
Language eng
Abstract Efficient motor control requires motor planning. Age-related changes in motor control are well described, e.g. increased movement variability and greater antagonistic muscle co-activation, as well as less functional and less regional specific brain activation. However, less is known about age-related changes in motor planning. By use of transcranial magnetic stimulation we investigated differences in corticomotor facilitation during motor planning in 17 young (25 ± 3 years) and 17 older healthy adults (70 ± 13 years) in a delayed movement paradigm for wrist movements. Motor evoked potentials (MEPs) were recorded for the flexor and extensor carpi radialis during movement preparation of wrist flexion and extension as well as during rest. We found that MEPs were less specifically facilitated during planning in older as compared to younger adults, as indicated by an Age × Condition × Muscle interaction. Young participants showed significantly facilitated MEPs in the respective muscle needed for wrist flexion or extension. By contrast MEPs in older participants were less specifically modulated. We conclude that age relates to dedifferentiated activation of the primary motor cortex already during preparation of distinct movements which might contribute to less efficient motor control in older adults.
Keyword Aging
Motor control
Motor-evoked-potentials
Corticospinal excitability
EMG
TMS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Human Movement and Nutrition Sciences Publications
 
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Created: Thu, 04 Jun 2015, 14:20:24 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences