Increased risk of psychosis in rural-born individuals: An Australian catchment-area study

McGrath, J., Cardy, S., Chapple, B. and Mowry, B. (2000). Increased risk of psychosis in rural-born individuals: An Australian catchment-area study. In: Schizophrenia Research: Biennial Winter Workshop on Schizophrenia. Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (20-20). 5 February - 11 February 2000. doi:10.1016/S0920-9964(00)90346-3


Author McGrath, J.
Cardy, S.
Chapple, B.
Mowry, B.
Title of paper Increased risk of psychosis in rural-born individuals: An Australian catchment-area study
Conference name Biennial Winter Workshop on Schizophrenia
Conference location Davos, Switzerland
Conference dates 5 February - 11 February 2000
Proceedings title Schizophrenia Research: Biennial Winter Workshop on Schizophrenia   Check publisher's open access policy
Journal name Schizophrenia Research   Check publisher's open access policy
Place of Publication Amsterdam
Publisher Elsevier
Publication Year 2000
DOI 10.1016/S0920-9964(00)90346-3
ISSN 0920-9964
Volume 41
Issue 1
Start page 20
End page 20
Total pages 1
Language eng
Abstract/Summary The aim of the Brisbane Psychosis Study was to examine a range of candidate genetic and nongenetic risk factors in a large, representative sample of patients with psychosis and well controls. The patients (n=310) were drawn from a census conducted as part of the National Survey of Mental Health and Wellbeing. An age and sex-matched well control group (n = 303) was drawn from the same catchment area. Candidate risk factors assessed included migrant status of proband and proband's parents, occupation of father at time of proband's birth, place of birth and place of residence during the first 5 years of life (urbanicity), self-reported pregnancy and birth complications, season of birth and family history. The main analyses were group (cases versus controls) comparisons, with planned subgroup analyses (1) group comparisons for Australian-born subjects only, (2) within-patient comparisons of affective versus nonaffective psychoses. Of the individuals with psychosis, 68% had DSMIII-R schizophrenia. In the main analyses, there were no significant group differences on season of birth, place of birth, place of residency in the first 5 years, occupation of fathers at time of birth or pregnancy and birth complications. Patients had significantly more family members with schizophrenia. Significantly fewer of the patients were migrants or offspring of migrants compared to the controls. When only Australianborn subjects were assessed (n=457), the findings were essentially unchanged apart from a significant excess of cases born in rural sites (chi-square=9.54, df3, p=0.02). There were no significant differences in the risk factors for the comparison involving affective versus nonaffective psychoses. Potential explanations for the inverse urban-rural risk gradient are reviewed. The Stanley Foundation supported this project
Subjects 110319 Psychiatry (incl. Psychotherapy)
Keyword Psychiatry
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Mon, 13 Aug 2007, 21:34:23 EST