Negative pressure wound therapy in the treatment of ulcerated infantile haemangioma

Fox, Carly M., Johnson, Bethan, Storey, Kristen, Das Gupta, Romi and Kimble, Roy (2015) Negative pressure wound therapy in the treatment of ulcerated infantile haemangioma. Pediatric Surgery International, 31 7: 653-658. doi:10.1007/s00383-015-3716-x

Author Fox, Carly M.
Johnson, Bethan
Storey, Kristen
Das Gupta, Romi
Kimble, Roy
Title Negative pressure wound therapy in the treatment of ulcerated infantile haemangioma
Journal name Pediatric Surgery International   Check publisher's open access policy
ISSN 1437-9813
Publication date 2015-05-13
Sub-type Article (original research)
DOI 10.1007/s00383-015-3716-x
Open Access Status Not yet assessed
Volume 31
Issue 7
Start page 653
End page 658
Total pages 6
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2016
Language eng
Formatted abstract
Background: Infantile haemangioma is a common benign tumour of infancy. Ulceration is the most common complication and is often painful and difficult to treat. Propranolol therapy is widely used to induce involution in rapidly growing or ulcerated lesions, or those in anatomically awkward locations. The ideal dressing regimen for these lesions would provide effective analgesia, act as a wound dressing, and aid involution of the primary lesion. To date, no ideal regimen has been established. Negative pressure wound therapy (NPWT) has been used in adult and paediatric populations to help improve wound healing in a variety of settings. It may provide a useful alternative to traditional dressing regimens in ulcerated infantile haemangioma.

Methods: Six consecutive patients with ulcerating infantile haemangioma presenting to the Royal Children’s Hospital vascular anomalies clinic were included in the study. Each patient was treated with a combination of NPWT and propranolol. Outcomes including time to wound healing, perceived ease of dressing management, and analgesia were recorded.

Results: Complete wound healing was obtained in all cases. Patient outcomes in terms of analgesia, comfort, and ease of wound dressing were improved following application of NPWT.

Discussion/Conclusions: We propose that this regimen represents a novel therapy for management of ulcerated infantile haemangioma. Possible mechanisms for healing effect, and improved analgesia are discussed. Further investigation is required to determine if negative pressure wound therapy results in faster healing times compared to traditional dressing regimens.
Keyword Infantile haemangioma
Negative pressure wound therapy
Vascular malformations
Wound healing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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