Epistatic interaction of BDNF and COMT on the frontostriatal system

Wang, C., Liu, B., Long, H., Fan, L., Li, J., Zhang, X., Qiu, C., Yu, C. and Jiang, T. (2015) Epistatic interaction of BDNF and COMT on the frontostriatal system. Neuroscience, 298 380-388. doi:10.1016/j.neuroscience.2015.04.014


Author Wang, C.
Liu, B.
Long, H.
Fan, L.
Li, J.
Zhang, X.
Qiu, C.
Yu, C.
Jiang, T.
Title Epistatic interaction of BDNF and COMT on the frontostriatal system
Journal name Neuroscience   Check publisher's open access policy
ISSN 1873-7544
0306-4522
Publication date 2015-07-09
Sub-type Article (original research)
DOI 10.1016/j.neuroscience.2015.04.014
Volume 298
Start page 380
End page 388
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Abstract The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system.
Keyword Brain-derived neurotrophic factor (BDNF)
Catechol-O-methyltransferase (COMT)
Dopamine
Frontostriatal system
Functional connectivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Advanced Imaging Publications
 
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