Bridging integrator 1 (BIN1) genotype effects on working memory, hippocampal volume, and functional connectivity in young healthy individuals

Zhang, Xiaolong, Yu, Jin-Tai, Li, Jin, Wang, Chao, Tan, Lan, Liu, Bing and Jiang, Tianzi (2015) Bridging integrator 1 (BIN1) genotype effects on working memory, hippocampal volume, and functional connectivity in young healthy individuals. Neuropsychopharmacology, 40 7: 1794-1803. doi:10.1038/npp.2015.30


Author Zhang, Xiaolong
Yu, Jin-Tai
Li, Jin
Wang, Chao
Tan, Lan
Liu, Bing
Jiang, Tianzi
Title Bridging integrator 1 (BIN1) genotype effects on working memory, hippocampal volume, and functional connectivity in young healthy individuals
Journal name Neuropsychopharmacology   Check publisher's open access policy
ISSN 1740-634X
0893-133X
Publication date 2015-02-18
Year available 2015
Sub-type Article (original research)
DOI 10.1038/npp.2015.30
Volume 40
Issue 7
Start page 1794
End page 1803
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Alzheimer’s disease (AD) is the most common form of dementia and exhibits a considerable level of heritability. The bridging integrator 1 (BIN1) gene has recently been identified in several large genome-wide association studies (GWAS) as the second most important risk locus for AD following apolipoprotein E (APOE). However, how and when the established genetic risk locus BIN1 rs744373 confers risk to late-onset AD has yet to be determined. Here using an imaging genetic strategy in large-sample Chinese subjects, we show that healthy homozygous carriers of the rs744373 risk allele exhibit worse high-load working memory (WM) performance, larger hippocampal volume and lower functional connectivity between the bilateral hippocampus and the right dorsolateral prefrontal cortex (DLPFC), mirroring clinical evidence of disturbed memory and connectivity in patients. Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.
Keyword Cognitive impairment
Alzheimer Disease
Working memory load
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Advanced Imaging Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 31 May 2015, 01:02:01 EST by System User on behalf of Scholarly Communication and Digitisation Service