Consensus nomenclature for CD8(+) T cell phenotypes in cancer

Apetoh, Lionel, Smyth, Mark J., Drake, Charles G., Abastado, Jean-Pierre, Apte, Ron N., Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H., Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P., Comin-Anduix, Begona, Coukos, Georges, Dhodapkar, Madhav V., Dranoff, Glenn, Frazer, Ian H., Fridman, Wolf-Herve, Gabrilovich, Dmitry I., Gilboa, Eli, Gnjatic, Sacha, Jaeger, Dirk, Kalinski, Pawel, Kaufman, Howard L., Kiessling, Rolf, Kirkwood, John, Knuth, Alexander, Liblau, Roland, Lotze, Michael T., Lugli, Enrico, Marincola, Francesco, Melero, Ignacio, Melief, Cornelis J., Mempel, Thorsten R., Mittendorf, Elizabeth A., Odun, Kunle, Overwijk, Willem W., Palucka, Anna Karolina, Parmiani, Giorgio, Ribas, Antoni, Romero, Pedro, Schreiber, Robert D., Schuler, Gerold, Srivastava, Pramod K., Tartour, Eric, Valmori, Danila, van der Burg, Sjoerd H., van der Bruggen, Pierre, van den Eynde, Benoit J., Wang, Ena, Zou, Weiping, Whiteside, Theresa L., Speiser, Daniel E., Pardoll, Drew M., Restifo, Nicholas P. and Anderson, Ana C. (2015) Consensus nomenclature for CD8(+) T cell phenotypes in cancer. Oncoimmunology, 4 4: e998538-1-e998538-10. doi:10.1080/2162402X.2014.998538


Author Apetoh, Lionel
Smyth, Mark J.
Drake, Charles G.
Abastado, Jean-Pierre
Apte, Ron N.
Ayyoub, Maha
Blay, Jean-Yves
Bonneville, Marc
Butterfield, Lisa H.
Caignard, Anne
Castelli, Chiara
Cavallo, Federica
Celis, Esteban
Chen, Lieping
Colombo, Mario P.
Comin-Anduix, Begona
Coukos, Georges
Dhodapkar, Madhav V.
Dranoff, Glenn
Frazer, Ian H.
Fridman, Wolf-Herve
Gabrilovich, Dmitry I.
Gilboa, Eli
Gnjatic, Sacha
Jaeger, Dirk
Kalinski, Pawel
Kaufman, Howard L.
Kiessling, Rolf
Kirkwood, John
Knuth, Alexander
Liblau, Roland
Lotze, Michael T.
Lugli, Enrico
Marincola, Francesco
Melero, Ignacio
Melief, Cornelis J.
Mempel, Thorsten R.
Mittendorf, Elizabeth A.
Odun, Kunle
Overwijk, Willem W.
Palucka, Anna Karolina
Parmiani, Giorgio
Ribas, Antoni
Romero, Pedro
Schreiber, Robert D.
Schuler, Gerold
Srivastava, Pramod K.
Tartour, Eric
Valmori, Danila
van der Burg, Sjoerd H.
van der Bruggen, Pierre
van den Eynde, Benoit J.
Wang, Ena
Zou, Weiping
Whiteside, Theresa L.
Speiser, Daniel E.
Pardoll, Drew M.
Restifo, Nicholas P.
Anderson, Ana C.
Title Consensus nomenclature for CD8(+) T cell phenotypes in cancer
Journal name Oncoimmunology   Check publisher's open access policy
ISSN 2162-402X
Publication date 2015
Sub-type Article (original research)
DOI 10.1080/2162402X.2014.998538
Open Access Status Not yet assessed
Volume 4
Issue 4
Start page e998538-1
End page e998538-10
Total pages 10
Place of publication New York, NY, United States
Publisher Taylor & Francis
Collection year 2016
Language eng
Formatted abstract
Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms “pro-tumor” and “antitumor.” Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+ T cells in cancer.
Keyword Anergy
Anticancer immunity
CD8(+) T cells
Cytotoxicity
Exhaustion
Effector
IFN gamma
Senescence
Stemness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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