Airway Inflammation is Augmented by Obesity and Fatty Acids in Asthma

Scott, H. A., Gibson, P. G., Garg, M. L. and Wood, L. G. (2011) Airway Inflammation is Augmented by Obesity and Fatty Acids in Asthma. European Respiratory Journal, 38 3: 594-602. doi:10.1183/09031936.00139810


Author Scott, H. A.
Gibson, P. G.
Garg, M. L.
Wood, L. G.
Title Airway Inflammation is Augmented by Obesity and Fatty Acids in Asthma
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
1399-3003
Publication date 2011-09
Year available 2011
Sub-type Article (original research)
DOI 10.1183/09031936.00139810
Open Access Status
Volume 38
Issue 3
Start page 594
End page 602
Total pages 9
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Formatted abstract
Obesity and asthma are associated, but the mechanism(s) of the association have yet to be elucidated. The aim of this study was to assess airway inflammation in relation to obesity and plasma fatty acids in males and females with and without asthma. Obese (n=68) and nonobese (n=47) adults with asthma, and obese (n=16) and nonobese (n=63) healthy controls had induced sputum and venous blood samples analysed for inflammatory markers. There was a positive interaction between obesity and asthma on sputum neutrophil percentage (p=0.012) and C-reactive protein level (p=0.003). Although sputum eosinophil percentage was elevated in asthma (p=0.001), there was no effect of obesity (p=0.16). Sputum neutrophil percentage was positively associated with body mass index in females with asthma (β=1.015, 95% CI 0.258-1.772; p=0.009) and neutrophilic asthma was present in a greater proportion of obese compared with non-obese females (42.9% versus 16.2%; p=0.017). In males with asthma, sputum neutrophil percentage was positively associated with total plasma saturated fatty acids (β=0.108, 95% CI 0.036-0.180; p=0.004) and negatively with monounsaturated fatty acids (β= -0.068, 95% CI -0.131- -0.005; p50.035). This was the first study to demonstrate an increase in neutrophilic airway inflammation in obese asthma. This relationship was significant only in females with asthma. In males, saturated and monounsaturated fatty acids were important predictors of neutrophilic airway inflammation in asthma.
Keyword Asthma
Inflammation
Leptin
Neutrophils
Obesity
Saturated fat
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Fri, 29 May 2015, 14:44:26 EST by Hayley Scott on behalf of Medicine - Princess Alexandra Hospital