Relationship between body composition, inflammation and lung function in overweight and obese asthma

Scott, Hayley A., Gibson, Peter G., Garg, Manohar L., Pretto, Jeffrey J., Morgan, Philip J., Callister, Robin and Wood, Lisa G. (2012) Relationship between body composition, inflammation and lung function in overweight and obese asthma. Respiratory Research, 13 10: . doi:10.1186/1465-9921-13-10


Author Scott, Hayley A.
Gibson, Peter G.
Garg, Manohar L.
Pretto, Jeffrey J.
Morgan, Philip J.
Callister, Robin
Wood, Lisa G.
Title Relationship between body composition, inflammation and lung function in overweight and obese asthma
Journal name Respiratory Research   Check publisher's open access policy
ISSN 1465-9921
1465-993X
Publication date 2012-02-01
Year available 2012
Sub-type Article (original research)
DOI 10.1186/1465-9921-13-10
Open Access Status DOI
Volume 13
Issue 10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Background: The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma.Methods: Overweight and obese (BMI 28-40 kg/m 2) adults with asthma (n = 44) completed lung function assessment and underwent full-body dual energy x-ray absorptiometry. Venous blood samples and induced sputum were analysed for inflammatory markers.Results: In females, android and thoracic fat tissue and total body lean tissue were inversely correlated with expiratory reserve volume (ERV). Conversely in males, fat tissue was not correlated with lung function, however there was a positive association between android and thoracic lean tissue and ERV. Lower body (gynoid and leg) lean tissue was positively associated with sputum %neutrophils in females, while leptin was positively associated with android and thoracic fat tissue in males.Conclusions: This study suggests that both body composition and inflammation independently affect lung function, with distinct differences between males and females. Lean tissue exacerbates the obese-asthma phenotype in females and the mechanism responsible for this finding warrants further investigation.
Keyword Adipose tissue
Dual energy x-ray absorptiometry
Leptin
Lung volume measurements
Neutrophil
Physiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Fri, 29 May 2015, 14:01:10 EST by Hayley Scott on behalf of Medicine - Princess Alexandra Hospital