Macrophage activation, age and gender effects of immunometabolism in obese asthma

Periyalil, Hashim A., Wood, Lisa G., Scott, Hayley A., Jensen, Megan E. and Gibson, Peter G. (2015) Macrophage activation, age and gender effects of immunometabolism in obese asthma. European Respiratory Journal, 45 2: 388-395. doi:10.1183/09031936.00080514


Author Periyalil, Hashim A.
Wood, Lisa G.
Scott, Hayley A.
Jensen, Megan E.
Gibson, Peter G.
Title Macrophage activation, age and gender effects of immunometabolism in obese asthma
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
1399-3003
Publication date 2015-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1183/09031936.00080514
Volume 45
Issue 2
Start page 388
End page 395
Total pages 8
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Collection year 2016
Language eng
Abstract Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma. Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines. Plasma CRP (p<0.01) and leptin (p<0.01) were elevated in obese asthmatic adults, and sCD163 (p=0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r=0.70, p=0.003) and obese female adults (r=0.65, p=0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r=-0.55, p=0.02) and was positively associated with the Asthma Control Questionnaire (r=0.57, p=0.02). Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level.
Keyword Asthma
Obesity
Immunometabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 28 May 2015, 13:08:30 EST by Hayley Scott on behalf of Medicine - Princess Alexandra Hospital