Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma

Scott, Hayley A., Latham, Jennifer R., Callister, Robin, Pretto, Jeffrey J., Baines, Katherine, Saltos, Nick, Upham, John W. and Wood, Lisa G. (2015) Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma. Annals of Allergy, Asthma and Immunology, 114 6: 470-479. doi:10.1016/j.anai.2015.04.002

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Scott, Hayley A.
Latham, Jennifer R.
Callister, Robin
Pretto, Jeffrey J.
Baines, Katherine
Saltos, Nick
Upham, John W.
Wood, Lisa G.
Title Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma
Journal name Annals of Allergy, Asthma and Immunology   Check publisher's open access policy
ISSN 1534-4436
1081-1206
Publication date 2015-06
Sub-type Article (original research)
DOI 10.1016/j.anai.2015.04.002
Volume 114
Issue 6
Start page 470
End page 479
Total pages 10
Place of publication New York, NY, United States
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Background: Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma.

Objective: To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma.

Methods: Fourteen adults with asthma (n = 6 physically inactive, n = 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours).

Results: Physically inactive participants had a significant decrease in eNO 4 hours after exercise (−4.8 ppb, −6.4 to −0.5 ppb, P = .028), which was not observed in physically active participants (P = .362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R = −0.685, P = .007) and 24 hours (R = −0.659, P = .014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2–like 2 gene expression were increased 2 hours after exercise in the overall cohort.

Conclusion: This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma.
Keyword Asthma
Exercise
Nitric oxide exhalation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 28 May 2015, 11:52:39 EST by Hayley Scott on behalf of Scholarly Communication and Digitisation Service