Sex determination in mammalian germ cells

Spiller, Cassy M. and Bowles, Josephine (2015) Sex determination in mammalian germ cells. Asian Journal of Andrology, 17 3: 427-432. doi:10.4103/1008-682X.150037

Author Spiller, Cassy M.
Bowles, Josephine
Title Sex determination in mammalian germ cells
Journal name Asian Journal of Andrology   Check publisher's open access policy
ISSN 1745-7262
Publication date 2015-05-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4103/1008-682X.150037
Open Access Status DOI
Volume 17
Issue 3
Start page 427
End page 432
Total pages 6
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2016
Language eng
Abstract Germ cells are the precursors of the sperm and oocytes and hence are critical for survival of the species. In mammals, they are specified during fetal life, migrate to the developing gonads and then undergo a critical period during which they are instructed, by the soma, to adopt the appropriate sexual fate. In a fetal ovary, germ cells enter meiosis and commit to oogenesis, whereas in a fetal testis, they avoid entry into meiosis and instead undergo mitotic arrest and mature toward spermatogenesis. Here, we discuss what we know so far about the regulation of sex-specific differentiation of germ cells, considering extrinsic molecular cues produced by somatic cells, as well as critical intrinsic changes within the germ cells. This review focuses almost exclusively on our understanding of these events in the mouse model.
Keyword Germ cells
Sex determination processes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
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