The role of hexosamine biosynthesis and signaling in early development

Pantaleon, Marie (2015). The role of hexosamine biosynthesis and signaling in early development. In Cell signaling during mammalian early embryo development (pp. 53-76) New York, NY, United States: Springer New York. doi:10.1007/978-1-4939-2480-6_3


Author Pantaleon, Marie
Title of chapter The role of hexosamine biosynthesis and signaling in early development
Title of book Cell signaling during mammalian early embryo development
Place of Publication New York, NY, United States
Publisher Springer New York
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4939-2480-6_3
Year available 2015
Series Advances in Experimental Medicine and Biology
ISBN 9781493924790
9781493924806
ISSN 0065-2598
2214-8019
Volume number 843
Chapter number 3
Start page 53
End page 76
Total pages 24
Total chapters 7
Collection year 2016
Language eng
Abstract/Summary Although the culture requirements and the metabolic profile of the preimplantation embryo have been thoroughly investigated since their first successful culture in a defined medium, now more than 50 years ago (Whitten, Nature 177:96, 1956), it is only recently that we have begun to appreciate the impact of the environment on life-course trajectory. The mechanisms involved in how nutrient availability may potentially modulate developmental potential are consequently not well defined. Originally thought of as simple energy substrates and biosynthetic precursors, the currently emerging paradigm suggests that nutrients may act in non-classical roles to impact on developmental potential. This is now an area of considerable activity thanks to pioneering epidemiological studies (Barker et al., BMJ 298:564–7, 1989) that have led to the establishment of the Developmental Origins of Health and Disease (DoHAD) hypothesis and a whole new field of research activity. The period prior to implantation is of particular interest as this has been identified as a critical window of developmental sensitivity to environmental or nutrient stress (Fleming et al., Biol Reprod 71:1046–54, 2004a). This review seeks specifically to explore the pivotal role of glucose in early mouse development and the mechanisms by which it may impact on the cellular functions of the developing embryo. The emerging paradigm suggests that this humble hexose sugar may be at the heart of a rather sophisticated mechanism of cellular control that not only impacts on cellular proliferation and viability in the short term but on cellular memory through to the next generation.
Keyword Early development
Embryo metabolism
Embryo viability
Embryonic programming
Gene regulation
Glucose signaling
Hexosamine biosynthesis
Hexosamine signaling
Nutrient sensing
O-linked glycosylation
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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