Bioanalytical evidence that chemicals in tattoo ink can induce adaptive stress responses

Neale Peta A., Stalter, Daniel, Tang, Janet Y. M. and Escher, Beate I. (2015) Bioanalytical evidence that chemicals in tattoo ink can induce adaptive stress responses. Journal of Hazardous Materials, 296 192-200. doi:10.1016/j.jhazmat.2015.04.051


Author Neale Peta A.
Stalter, Daniel
Tang, Janet Y. M.
Escher, Beate I.
Title Bioanalytical evidence that chemicals in tattoo ink can induce adaptive stress responses
Journal name Journal of Hazardous Materials   Check publisher's open access policy
ISSN 1873-3336
0304-3894
Publication date 2015-10-15
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.jhazmat.2015.04.051
Open Access Status
Volume 296
Start page 192
End page 200
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Tattooing is becoming increasingly popular, particularly amongst young people. However, tattoo inks contain a complex mixture of chemical impurities that may pose a long-term risk for human health. As a first step towards the risk assessment of these complex mixtures we propose to assess the toxicological hazard potential of tattoo ink chemicals with cell-based bioassays. Targeted modes of toxic action and cellular endpoints included cytotoxicity, genotoxicity and adaptive stress response pathways. The studied tattoo inks, which were extracted with hexane as a proxy for the bioavailable fraction, caused effects in all bioassays, with the red and yellow tattoo inks having the greatest response, particularly inducing genotoxicity and oxidative stress response endpoints. Chemical analysis revealed the presence of polycyclic aromatic hydrocarbons in the tested black tattoo ink at concentrations twice the recommended level. The detected polycyclic aromatic hydrocarbons only explained 0.06% of the oxidative stress response of the black tattoo ink, thus the majority of the effect was caused by unidentified components. The study indicates that currently available tattoo inks contain components that induce adaptive stress response pathways, but to evaluate the risk to human health further work is required to understand the toxicokinetics of tattoo ink chemicals in the body.
Keyword Tattoo ink
Bioanalytical tools
Polycyclic aromatic hydrocarbon
Genotoxicity
Oxidative stress
Cytotoxicity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
National Research Centre for Environmental Toxicology Publications
 
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