Body composition as determinant of thrombin generation in plasma: The hoorn study

Beijers, Hanneke J. B. H., Ferreira, Isabel, Spronk, Henri M. H., Bravenboer, Bert, Dekker, Jacqueline M., Nijpels, Giel, ten Cate, Hugo and Stehouwer, Coen D. A. (2010) Body composition as determinant of thrombin generation in plasma: The hoorn study. Arteriosclerosis, Thrombosis, and Vascular Biology, 30 12: 2639-2647. doi:10.1161/ATVBAHA.110.211946

Author Beijers, Hanneke J. B. H.
Ferreira, Isabel
Spronk, Henri M. H.
Bravenboer, Bert
Dekker, Jacqueline M.
Nijpels, Giel
ten Cate, Hugo
Stehouwer, Coen D. A.
Title Body composition as determinant of thrombin generation in plasma: The hoorn study
Journal name Arteriosclerosis, Thrombosis, and Vascular Biology   Check publisher's open access policy
ISSN 1079-5642
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.1161/ATVBAHA.110.211946
Open Access Status
Volume 30
Issue 12
Start page 2639
End page 2647
Total pages 9
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Language eng
Abstract Objective- The association between obesity and cardiovascular disease and venous thromboembolism might, at least partially, be explained by a hypercoagulable state. The extent to which body fat mass and its distribution contribute to a hypercoagulable state is unknown. In this study, we investigated the association between body composition and thrombin generation and evaluated the potential mediating role of low-grade inflammation. Methods and Results- We studied 586 individuals from the Hoorn Study (mean age, 69.7±6.5 years, 298 women) in whom body composition was assessed by whole body dual-energy absorptiometry. Thrombin generation was measured using the Calibrated Automated Thrombogram. Multiple regression analyses showed a positive association between total body fat and thrombin generation in women but not in men. In addition, detailed analyses of regional body composition showed that central but not peripheral fat mass was associated with greater thrombin generation and that there was a trend toward an inverse association with peripheral lean mass. The reported positive associations were partially attenuated by low-grade inflammation, however. Conclusion- Body fat mass, in particular a central pattern of fat distribution, is associated with higher levels of thrombin generation in elderly women but not in men. This association may partially be explained by adiposity-related low-grade inflammation, but this hypothesis needs to be further investigated in mechanistic/prospective studies.
Keyword Body composition
Dual energy X ray absorptiometry
Endogenous thrombin potential
Thrombin Generation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Created: Wed, 20 May 2015, 16:42:58 EST by Isabel Ferreira on behalf of School of Public Health