Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period

van Bussel, Bas C., Schouten, Fleur, Henry, Ronald M., Schalkwijk, Casper G., de Boer, Michiel R., Ferreira, Isabel, Smulders, Yvo M., Twisk, Jos W. and Stehouwer, Coen D. (2011) Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. Hypertension, 58 4: 588-595. doi:10.1161/HYPERTENSIONAHA.111.174557


Author van Bussel, Bas C.
Schouten, Fleur
Henry, Ronald M.
Schalkwijk, Casper G.
de Boer, Michiel R.
Ferreira, Isabel
Smulders, Yvo M.
Twisk, Jos W.
Stehouwer, Coen D.
Title Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period
Journal name Hypertension   Check publisher's open access policy
ISSN 0194-911X
1524-4563
Publication date 2011
Year available 2011
Sub-type Article (original research)
DOI 10.1161/HYPERTENSIONAHA.111.174557
Open Access Status
Volume 58
Issue 4
Start page 588
End page 595
Total pages 8
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins
Language eng
Abstract Endothelial dysfunction and low-grade inflammation are associated with cardiovascular disease. Arterial stiffening plays an important role in cardiovascular disease and, thus, may be a mechanism through which endothelial dysfunction and/or low-grade inflammation lead to cardiovascular disease. We investigated the associations between, on the one hand, biomarkers of endothelial dysfunction (soluble endothelial selectin, thrombomodulin, and both vascular and intercellular adhesion molecules 1 and von Willebrand factor) and of low-grade inflammation (C-reactive protein, serum amyloid A, interleukin 6, interleukin 8, tumor necrosis factor-α and, soluble intercellular adhesion molecule 1) and, on the other hand, arterial stiffness over a 6-year period, in 293 healthy adults (155 women). Biomarkers were combined into mean z scores. Carotid, femoral, and brachial arterial stiffness and carotid-femoral pulse wave velocity were determined by ultrasonography. Measurements were obtained when individuals were 36 and 42 years of age. Associations were analyzed with generalized estimating equation and adjusted for sex, height, and mean arterial pressure. The endothelial dysfunction z score was inversely associated with femoral distensibility (β:-0.51 [95% CI:-0.95 to-0.06]) and compliance coefficients (β:-0.041 [95% CI:-0.076 to-0.006]) but not with carotid or brachial stiffness or carotid-femoral pulse wave velocity. The low-grade inflammation z score was inversely associated with femoral distensibility (β:-0.51 [95% CI:-0.95 to-0.07]) and compliance coefficients (β:-0.050 [95% CI:-0.084 to-0.016]) and with carotid distensibility coefficient (β:-0.910 [95% CI:-1.810 to-0.008]) but not with brachial stiffness or carotid-femoral pulse wave velocity. Biomarkers of endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness. This provides evidence that arterial stiffening may be a mechanism through which endothelial dysfunction and low-grade inflammation lead to cardiovascular disease.
Keyword Arteriosclerosis
Endothelial dysfunction
Epidemiology
Inflammation
Prospective study
Young adulthood
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 20 May 2015, 16:30:56 EST by Isabel Ferreira on behalf of School of Public Health