Continuing smoking between adolescence and young adulthood is associated with higher arterial stiffness in young adults: The Northern Ireland Young Hearts Project

van de Laar, Roel J. J., Stehouwer, Coen D. A., Boreham, Colin A., Murray, Liam M., Schalkwijk, Casper G., Prins, Martin H., Twisk, Jos W. R. and Ferreira, Isabel (2011) Continuing smoking between adolescence and young adulthood is associated with higher arterial stiffness in young adults: The Northern Ireland Young Hearts Project. Journal of Hypertension, 29 11: 2201-2209. doi:10.1097/HJH.0b013e32834b0ecf


Author van de Laar, Roel J. J.
Stehouwer, Coen D. A.
Boreham, Colin A.
Murray, Liam M.
Schalkwijk, Casper G.
Prins, Martin H.
Twisk, Jos W. R.
Ferreira, Isabel
Title Continuing smoking between adolescence and young adulthood is associated with higher arterial stiffness in young adults: The Northern Ireland Young Hearts Project
Journal name Journal of Hypertension   Check publisher's open access policy
ISSN 0263-6352
1473-5598
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1097/HJH.0b013e32834b0ecf
Volume 29
Issue 11
Start page 2201
End page 2209
Total pages 9
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins
Language eng
Abstract Objectives: To investigate the associations between smoking in adolescence and adulthood, and changes in smoking behaviour between these age periods, with arterial stiffness in young adults; and whether any such associations could be explained by concomitant smoking-related levels of inflammation and endothelial dysfunction. Methods: We studied 424 individuals (216 women) in whom smoking status was assessed in adolescence (age 15 years) and again in young adulthood (mean age of 22.6 ± 1.6 years), along with aorto-iliac, aorto-radial, and aorto-dorsalis pedis pulse wave velocity (PWV), and markers of inflammation (i.e. C-reactive protein and fibrinogen) and endothelial dysfunction (i.e. von Willebrand factor and tissue-plasminogen activator antigen) in young adulthood only. Results: Smoking in adolescence was associated with higher aorto-iliac PWV, as well as with inflammation and endothelial dysfunction levels (expressed as two scores), independently of other adolescent and adult lifestyles. Compared with never smokers, continuing smokers, but not starters nor quitters, showed higher aorto-iliac PWV, independent of changes in other lifestyle variables: +0.157 m/s (95% confidence interval 0.026-0.288). This difference was attenuated to 0.124 m/s (-0.009 to 0.257) after adjustment for changes in traditional biological risk factors, but was not materially affected when adjusted for the inflammation and endothelial dysfunction scores, despite the continuing smoking-related higher levels of inflammation and endothelial dysfunction. Smoking was not associated with aorto-radial and aorto-dorsalis pedis PWV. Conclusion: Starting to smoke in adolescence and continuing to do so up to young adulthood is adversely associated with aortic stiffness. The continuing smoking-related aortic stiffness was not explained by concomitant higher inflammation and endothelial dysfunction. Prevention of smoking should target the young to prevent arterial stiffness in young adults.
Keyword Adolescence
Arterial stiffness
Epidemiology
Lifestyle
Smoking
Young adulthood
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Thu, 21 May 2015, 02:28:48 EST by Isabel Ferreira on behalf of School of Public Health