Abdominal fat mass is associated with adaptive immune activation: The CODAM study

Thewissen, Marielle M., Damoiseaux, Jan G., Duijvestijn, Adriaan M., van Greevenbroek, Marleen M., van der Kallen, Carla J., Feskens, Edith J., Blaak, Ellen E., Schalkwijk, Casper G., Stehouwer, Coen D., Tervaert, Jan W. Cohen and Ferreira, Isabel (2011) Abdominal fat mass is associated with adaptive immune activation: The CODAM study. Obesity, 19 8: 1690-1698. doi:10.1038/oby.2010.337

Author Thewissen, Marielle M.
Damoiseaux, Jan G.
Duijvestijn, Adriaan M.
van Greevenbroek, Marleen M.
van der Kallen, Carla J.
Feskens, Edith J.
Blaak, Ellen E.
Schalkwijk, Casper G.
Stehouwer, Coen D.
Tervaert, Jan W. Cohen
Ferreira, Isabel
Title Abdominal fat mass is associated with adaptive immune activation: The CODAM study
Journal name Obesity   Check publisher's open access policy
ISSN 1930-7381
Publication date 2011
Year available 2011
Sub-type Article (original research)
DOI 10.1038/oby.2010.337
Open Access Status
Volume 19
Issue 8
Start page 1690
End page 1698
Total pages 9
Place of publication Hoboken, NJ United States
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Abdominal fat-related activation of the innate immune system and insulin resistance (IR) are implicated in the pathogenesis of cardiovascular diseases. Recent data support an important role of the adaptive immune system as well. In this study, we investigate the association between waist circumference and markers of systemic adaptive immune activation, and the potential mediating role of innate immune activation and/or IR herein. The study population consisted of 477 (304 men) individuals (mean age: 59.4±7.0 years) in whom waist circumference, HOMA2-IR (IR derived from homeostasis model assessment), and markers of innate (C-reactive protein (CRP), interleukin (IL)-6, serum amyloid A (SAA)) and adaptive (neopterin, soluble CD25 (sCD25)) immune activation were measured. These markers were compiled into an adaptive and innate immune activation score by averaging the respective z-scores. After adjustments for age, sex, glucose metabolism, smoking status, prior cardiovascular disease, and other risk factors, waist circumference was associated with the adaptive (standardized regression coefficient Β = 0.12 (95% confidence intervals: 0.04-0.20)) and the innate immune activation scores (Β = 0.24 (0.17-0.31)), and with HOMA2-IR (Β = 0.49 (0.42-0.56)). The innate immune activation score and HOMA2-IR were also positively associated with the adaptive immune activation score (Β = 0.31 (0.21-0.40) and Β = 0.11 (0.02-0.21), respectively). The association between waist circumference and the adaptive immune activation score was completely abolished when further adjusted for innate immune activation and HOMA2-IR (to Β = 0.01 (0.10-0.08)), and the specific mediation effects attributable to each of these variables were 58% and 42%, respectively. We conclude that abdominal obesity is associated with systemic adaptive immune activation and that innate immune activation and IR constitute independent and equally important pathways explaining this association.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Created: Wed, 20 May 2015, 16:10:07 EST by Isabel Ferreira on behalf of School of Public Health