Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: Potential role of central adiposity and low-grade inflammation - The Hoorn Study

Beijers, Hanneke J. B. H., Ferreira, Isabel, Spronk, Henri M. H., Bravenboer, Bert, Dekker, Jacqueline M., Nijpels, Giel, ten Cate, Hugo and Stehouwer, Coen D. A. (2012) Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: Potential role of central adiposity and low-grade inflammation - The Hoorn Study. Thrombosis Research, 129 5: 557-562. doi:10.1016/j.thromres.2011.07.033


Author Beijers, Hanneke J. B. H.
Ferreira, Isabel
Spronk, Henri M. H.
Bravenboer, Bert
Dekker, Jacqueline M.
Nijpels, Giel
ten Cate, Hugo
Stehouwer, Coen D. A.
Title Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: Potential role of central adiposity and low-grade inflammation - The Hoorn Study
Journal name Thrombosis Research   Check publisher's open access policy
ISSN 0049-3848
1879-2472
Publication date 2012
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.thromres.2011.07.033
Open Access Status
Volume 129
Issue 5
Start page 557
End page 562
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Introduction: Type 2 diabetes (DM2) is associated with greater risk for cardiovascular disease (CVD), which may, at least partially, be explained by prothrombotic alterations. We therefore investigated; first, the extent to which individuals with impaired glucose metabolism (IGM) and/or DM2 had greater levels of thrombin generation than those with normal glucose metabolism (NGM); and second, whether any differences were independent of other cardiovascular risk factors, such as smoking, hypertension, dyslipidaemia, (micro)albuminuria, glycemic control and (central) adiposity, and/or were potentially 'mediated' by low-grade inflammation (high-sensitivity C-reactive protein (hsCRP)). Materials and methods: We studied 744 individuals from the Hoorn Study (275 NGM, 176 IGM and 293 DM2, mean age 68.6 ± 7.1 years). Thrombin generation in platelet-poor plasma was measured using the Calibrated Automated Thrombogram and three parameters were derived: lag time, peak height and endogenous thrombin potential (ETP). Data were analyzed with multiple linear regression analyses. Results: After adjustment for age, sex, prior CVD and smoking status, individuals with IGM or DM2 had a longer lag time [ß = 0.14 min (95% CI: 0.02; 0.26)], higher peak height [ß = 7.29 nM (- 1.33; 15.91)] and ETP [ß = 35.65nM*min (0.97; 70.34)] than those with NGM. These differences were attenuated to ß = 0.06 min (- 0.07; 0.19), 3.82 nM (- 5.46; 13.10) and 16.34 nM*min (- 20.92; 53.59), respectively, when further adjusted for waist circumference and hsCRP. Conclusion: Individuals with IGM or DM2 had up to 4% higher thrombin generation compared with NGM, which may be explained, to a great extent, by the greater levels of central adiposity and related low-grade inflammation characterizing these individuals.
Keyword Endogenous thrombin potential (ETP)
Epidemiology
Thrombin generation
Type 2 diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 20 May 2015, 15:32:23 EST by Isabel Ferreira on behalf of School of Public Health