Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors

Engelen, Lian, Ferreira, Isabel, Stehouwer, Coen D., Boutouyrie, Pierre and Laurent, Stephane (2013) Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors. European Heart Journal, 34 30: 2368-2380. doi:10.1093/eurheartj/ehs380


Author Engelen, Lian
Ferreira, Isabel
Stehouwer, Coen D.
Boutouyrie, Pierre
Laurent, Stephane
Title Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors
Journal name European Heart Journal   Check publisher's open access policy
ISSN 0195-668X
1522-9645
Publication date 2013-08-07
Year available 2013
Sub-type Article (original research)
DOI 10.1093/eurheartj/ehs380
Open Access Status
Volume 34
Issue 30
Start page 2368
End page 2380
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2014
Language eng
Abstract Aims Common carotid artery intima-media thickness (CCIMT) is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease (CVD). The interpretation of CCIMT values has been hampered by the absence of reference values, however. We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures. Methods and results We combined CCIMT data obtained by echotracking on 24 871 individuals (53% men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n 1/4 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference subpopulations, thereby allowing for a standardized comparison between observed and predicted ('normal') values from individuals of the same age and sex. In the sub-population without CVD and treatment (n 1/4 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized bs 0.19 (95% CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)]. Conclusion We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CVRFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.
Keyword Ageing
Atherosclerois
Echotracking
Reference intervals
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 20 May 2015, 15:27:03 EST by Isabel Ferreira on behalf of School of Public Health