Plasma levels of advanced glycation endproducts Nε-(carboxymethyl) lysine, Nε-(carboxyethyl)lysine, and pentosidine are not independently associated with cardiovascular disease in individuals with or without type 2 diabetes: The hoorn and CODAM studies

Hanssen, Nordin M. J., Engelen, Lian, Ferreira, Isabel, Scheijen, Jean L. J. M., Huijberts, Maya S., van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Dekker, Jacqueline M., Nijpels, Giel, Stehouwer, Coen D. A. and Schalkwijk, Casper G. (2013) Plasma levels of advanced glycation endproducts Nε-(carboxymethyl) lysine, Nε-(carboxyethyl)lysine, and pentosidine are not independently associated with cardiovascular disease in individuals with or without type 2 diabetes: The hoorn and CODAM studies. Journal of Clinical Endocrinology and Metabolism, 98 8: E1369-E1373. doi:10.1210/jc.2013-1068


Author Hanssen, Nordin M. J.
Engelen, Lian
Ferreira, Isabel
Scheijen, Jean L. J. M.
Huijberts, Maya S.
van Greevenbroek, Marleen M. J.
van der Kallen, Carla J. H.
Dekker, Jacqueline M.
Nijpels, Giel
Stehouwer, Coen D. A.
Schalkwijk, Casper G.
Title Plasma levels of advanced glycation endproducts Nε-(carboxymethyl) lysine, Nε-(carboxyethyl)lysine, and pentosidine are not independently associated with cardiovascular disease in individuals with or without type 2 diabetes: The hoorn and CODAM studies
Journal name Journal of Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0021-972X
1945-7197
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1210/jc.2013-1068
Open Access Status DOI
Volume 98
Issue 8
Start page E1369
End page E1373
Total pages 5
Place of publication Chevy Chase, MD United States
Publisher The Endocrine Society
Collection year 2014
Language eng
Abstract Objective: Experimental and histological data suggest a role for advanced glycation end products (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, the epidemiological evidence of an adverse association between AGEs and CVD remains inconclusive. We therefore investigated, in individuals with various degrees of glucose metabolism, the associations of plasma AGEs with prevalent CVD. Research Design and Methods: We measured plasma levels of protein-bound Nε-(carboxymethyl)lysine (CML),Nε-(carboxyethyl)lysine (CEL), and pentosidine, in participants from two Dutch cohort studies (n=1291, mean age 64.7±8.3 years, 45% women), including 573 individuals with normal glucose metabolism, 304 with impaired glucose metabolism, and 414 with T2DM. In addition, we measured free CML, CEL, and 5-hydro-5-methylimidazolone in a subset of participants (n=554). Data were analyzed with multiple logistic or linear regression analyses. Results: CEL (32 [interquartile range: 25-40] vs 28 [22-35] nmol/mmol lysine) and pentosidine (0.53 [0.43-0.67] vs 0.48 [0.40-0.59] nmol/mmol lysine) as well as free CEL (48 [39-62] vs 45 [36-56] nmol/L) and 5-hydro-5-methylimidazolone (141 [96-209] vs 116 [84-165] nmol/L) were higher in individuals with vs without CVD, whereas protein-bound CML was lower (33 [27-38] vs 34 [29-39] nmol/mmol lysine). However, these differences disappeared after adjustment for confounders. The associations did not differ consistently between individuals with and without T2DM. Conclusions: We found no independent adverse associations of plasma AGEs with CVD in individuals with normal glucose metabolism, impaired glucose metabolism, and T2DM. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 20 May 2015, 15:24:44 EST by Isabel Ferreira on behalf of School of Public Health