Bc/I glucocorticoid receptor polymorphism is associated with greater body fatness: The hoorn and CODAM studies

Geelen, C. C., van Greevenbroek, M. M., van Rossum, E. F., Schaper, N. C., Nijpels, G., 't Hart, L. M., Schalkwijk, C. G., Ferreira, I., van der Kallen, C. J., Sauerwein, H. P., Dekker, J. M., Stehouwer, C. D. and Havekes, B. (2013) Bc/I glucocorticoid receptor polymorphism is associated with greater body fatness: The hoorn and CODAM studies. Journal of Clinical Endocrinology and Metabolism, 98 3: E595-E599. doi:10.1210/jc.2012-3442

Author Geelen, C. C.
van Greevenbroek, M. M.
van Rossum, E. F.
Schaper, N. C.
Nijpels, G.
't Hart, L. M.
Schalkwijk, C. G.
Ferreira, I.
van der Kallen, C. J.
Sauerwein, H. P.
Dekker, J. M.
Stehouwer, C. D.
Havekes, B.
Title Bc/I glucocorticoid receptor polymorphism is associated with greater body fatness: The hoorn and CODAM studies
Journal name Journal of Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1210/jc.2012-3442
Open Access Status
Volume 98
Issue 3
Start page E595
End page E599
Total pages 5
Place of publication Chevy Chase, MD United States
Publisher The Endocrine Society
Collection year 2014
Language eng
Abstract Context: The Bc/I polymorphism in the glucocorticoid receptor (GR) gene is associated with enhanced glucocorticoid (GC) sensitivity. Objective: Our objective was to investigate the association of the Bc/I polymorphism with body fatness and insulin resistance. Design and Setting: We conducted an observational cohort study, combining data from 2 cohort studies enriched with individuals with impaired glucose metabolism and/or diabetes mellitus type 2 (DM2). Patients and Methods: We examined 1228 participants (mean age 64.7 years, 45% women) from the Cohort Study on Diabetes and Atherosclerosis Maastricht (CODAM, n = 543) and the Hoorn Study (n=685). Body mass index (BMI), waist and hip circumferences, and waist-to-hip ratio (WHR) were obtained; insulin resistance was estimated using the homeostasis model assessment for insulin resistance (HOMA2-IR). Results: We identified 519 noncarriers (CC), 540 heterozygous (CG) carriers, and 169 homozygous (GG) carriers of the G-allele of the Bc/I polymorphism. Homozygous carriers had a higher BMI (28.9 vs 27.9 kg/m2) and waist (99.6 vs 97.2 cm) and hip (105.5 vs 103.2 cm) circumference compared with noncarriers, also after adjustment for age, sex, cohort, glucose tolerance, and lifestyle risk factors: β = 0.94 kg/m 2 (95% confidence interval, 0.24-1.63), β = 2.84 cm (0.95;4.73) and β = 2.38 cm (0.88-3.87), respectively. Similar results were obtained when comparing homozygous carriers with heterozygous carriers: β = 1.03 kg/m2 (0.34-1.72), β = 2.20 cm (0.31-4.08) and β = 1.99 cm (0.51-3.48), respectively. There were no differences in WHR. Ln-HOMA2-IR was higher in GG carriers compared with CG carriers; 0.29 vs 0.17 [β = 0.09 (0.01-0.17)], but this effect was attenuated after adjustment for BMI [β = 0.04 (-0.04 to 0.11)]. Conclusion: Homozygous carriers of the Bc/I polymorphism of the GR gene have significantly greater total body fatness, contributing to higher HOMA2-IR, compared with heterozygous carriers and noncarriers. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Created: Wed, 20 May 2015, 15:06:23 EST by Isabel Ferreira on behalf of School of Public Health