Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors

Herbert, Annie, Cruickshank, John Kennedy, Laurent, Stephane, Boutouyrie, Pierre, The Reference Values for Arterial Measurements Collaboration and Ferreira, Isabel (2014) Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal, 35 44: 3122-3133. doi:10.1093/eurheartj/ehu293


Author Herbert, Annie
Cruickshank, John Kennedy
Laurent, Stephane
Boutouyrie, Pierre
The Reference Values for Arterial Measurements Collaboration
Ferreira, Isabel
Title Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors
Journal name European Heart Journal   Check publisher's open access policy
ISSN 0195-668X
1522-9645
Publication date 2014-11-21
Year available 2014
Sub-type Article (original research)
DOI 10.1093/eurheartj/ehu293
Open Access Status
Volume 35
Issue 44
Start page 3122
End page 3133
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2015
Language eng
Formatted abstract
Aims Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated.
Methods and results Existing data from population surveys and clinical trials were combined, whether published or not. Reference values of cSBP and amplification were calculated as percentiles for ‘Normal’ (no CVRFs) and ‘Reference’ (any CVRFs) populations. We included 45 436 subjects out of 82 930 that were gathered from 77 studies of 53 centres. Included subjects were apparently healthy, not treated for hypertension or dyslipidaemia, and free from overt CV disease and diabetes. Values of cSBP and amplification were stratified by brachial blood pressure categories and age decade in turn, both being stratified by sex. Amplification decreased with age and more so in males than in females. Sex was the most powerful factor associated with amplification with 6.6 mmHg (5.8–7.4) higher amplification in males than in females. Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose.
Conclusion Typical values of cSBP and amplification in a healthy population and a population free of traditional CVRFs are now available according to age, sex, and brachial BP, providing values included from different devices with a wide geographical representation. Amplification is significantly influenced by CVRFs, but differently in men and women.
Keyword Adult
Aged
Aorta
Arteries
Arteriosclerosis
Blood pressure
Central pressure
Humans
Pulse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 20 May 2015, 14:47:11 EST by Isabel Ferreira on behalf of School of Public Health