Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population

Hamad, Mohamed A. Soliman, van Straten, Albert H. M., Schoenberger, Jacques P. A. M., ter Woorst, Joost F., de Wolf, Andre M., Martens, Elisabeth J. and van Zundert, Andre A. J. (2010) Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population. Journal of Cardiothoracic Surgery, 5 1: . doi:10.1186/1749-8090-5-29


Author Hamad, Mohamed A. Soliman
van Straten, Albert H. M.
Schoenberger, Jacques P. A. M.
ter Woorst, Joost F.
de Wolf, Andre M.
Martens, Elisabeth J.
van Zundert, Andre A. J.
Title Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population
Journal name Journal of Cardiothoracic Surgery   Check publisher's open access policy
ISSN 1749-8090
Publication date 2010-04-23
Year available 2010
Sub-type Article (original research)
DOI 10.1186/1749-8090-5-29
Open Access Status DOI
Volume 5
Issue 1
Total pages 8
Place of publication London, United Kingdom
Publisher BioMed Centra
Language eng
Abstract Background: Preoperative left ventricular dysfunction is an established risk factor for early and late mortality after revascularization. This retrospective analysis demonstrates the effects of preoperative ejection fraction on the short-term and long-term survival of patients after coronary artery bypass grafting.Methods: Early and late mortality were determined retrospectively in 10 626 consecutive patients who underwent isolated coronary bypass between January 1998 and December 2007. The subjects were divided into 3 groups according to their preoperative ejection fraction. Expected survival was estimated by comparison with a general Dutch population group described in the database of the Dutch Central Bureau for Statistics. For each of our groups with a known preoperative ejection fraction, a general Dutch population group was matched for age, sex, and year of operation.Results and Discussion: One hundred twenty-two patients were lost to follow-up. In 219 patients, the preoperative ejection fraction could not be retrieved. In the remaining patients (n = 10 285), the results of multivariate logistic regression and Cox regression analysis identified the ejection fraction as a predictor of early and late mortality. When we compared long-term survival and expected survival, we found a relatively poorer outcome in all subjects with an ejection fraction of < 50%. In subjects with a preoperative ejection fraction of > 50%, long-term survival exceeded expected survival.Conclusions: The severity of left ventricular dysfunction was associated with poor survival. Compared with the survival of the matched general population, our coronary bypass patients had a worse outcome only if their preoperative ejection fraction was < 50%.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 20 May 2015, 12:14:09 EST by Andre Van Zundert on behalf of Anaesthesiology and Critical Care - RBWH