Preoperative Atrial Fibrillation and Elevated C-Reactive Protein Levels as Predictors of Mediastinitis After Coronary Artery Bypass Grafting

Elenbaas, Ted W. O., Soliman Hamad, Mohamed A., Schonberger, Jacques P. A. M., Martens, Elisabeth J., van Zundert, Andre A. J. and van Straten, Albert H. M. (2010) Preoperative Atrial Fibrillation and Elevated C-Reactive Protein Levels as Predictors of Mediastinitis After Coronary Artery Bypass Grafting. Annals of Thoracic Surgery, 89 3: 704-709. doi:10.1016/j.athoracsur.2009.12.013


Author Elenbaas, Ted W. O.
Soliman Hamad, Mohamed A.
Schonberger, Jacques P. A. M.
Martens, Elisabeth J.
van Zundert, Andre A. J.
van Straten, Albert H. M.
Title Preoperative Atrial Fibrillation and Elevated C-Reactive Protein Levels as Predictors of Mediastinitis After Coronary Artery Bypass Grafting
Journal name Annals of Thoracic Surgery   Check publisher's open access policy
ISSN 0003-4975
1552-6259
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.athoracsur.2009.12.013
Open Access Status
Volume 89
Issue 3
Start page 704
End page 709
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Elsevier
Language eng
Abstract Background: Mediastinitis is a serious complication after coronary artery bypass grafting (CABG). We studied the risk factors for the development of postoperative mediastinitis in a large group of patients who underwent isolated CABG at Catharina Hospital, Eindhoven, The Netherlands. Methods: Data of all patients undergoing an isolated CABG between January 1998 and December 2008 were analyzed. Univariate and multivariate logistic regression analyses were performed to investigate the effect of biomedical variables on the development of mediastinitis. Multivariate analyses were used to test for the confounding effect of various risk factors on outcomes. Results: Mediastinitis was present in 100 out of the 11,748 patients. Preoperative atrial fibrillation [odds ratio = 4.26 (2.26 to 8.02)] and an elevated preoperative C-reactive protein level [odds ratio = 1.013 (1.007 to 1.020)] were important independent predictors of the development of mediastinitis. Other significant risk factors were the following: age, chronic obstructive pulmonary disease, diabetes, morbid obesity, use of extracorporeal circulation, use of bilateral internal mammary arteries, reexploration for ischemia, and perioperative myocardial infarction. Conclusions: Apart from previously described risk factors for the development of postoperative mediastinitis, we found preoperative atrial fibrillation and an elevated C-reactive protein level to be significant predictors of mediastinitis in patients undergoing CABG.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 20 May 2015, 11:03:59 EST by Andre Van Zundert on behalf of Anaesthesiology and Critical Care - RBWH