Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol

Wilkinson, Ashley S., Taing, Meng-Wong, Pierson, Jean Thomas, Lin, Chun-Nam, Dietzgen, Ralf G., Shaw, P. Nicholas, Gidley, Michael J., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2015) Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol. Food and Function, 6 6: 1847-1854. doi:10.1039/c5fo00133a

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Author Wilkinson, Ashley S.
Taing, Meng-Wong
Pierson, Jean Thomas
Lin, Chun-Nam
Dietzgen, Ralf G.
Shaw, P. Nicholas
Gidley, Michael J.
Monteith, Gregory R.
Roberts-Thomson, Sarah J.
Title Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol
Journal name Food and Function   Check publisher's open access policy
ISSN 2042-6496
2042-650X
Publication date 2015-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1039/c5fo00133a
Open Access Status Not Open Access
Volume 6
Issue 6
Start page 1847
End page 1854
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2016
Language eng
Formatted abstract
Mango fruit contain many bioactive compounds, some of which are transcription factor regulators. Estrogen receptor alpha (ERα) and beta (ERβ) are two regulators of gene transcription that are important in a variety of physiological processes andalso in diseases including breast cancer. We examined the ability of the mango constituents quercetin, mangiferin, andthe aglycone form of mangiferin, norathyriol, to activate both isoforms of the estrogen receptor. Quercetin and norathyrioldecreased the viability of MCF-7 breast cancer cells whereas mangiferin had no effect on MCF-7 cells. We alsodetermined that quercetin and mangiferin selectively activated ERα whereas norathyriol activated both ERα and ERβ.Despite quercetin, mangiferin and norathyriol having similar polyphenolic structural motifs, only norathyriol activated ERβ, showing that bioactive agents in mangoes have very specific biological effects. Such specificity may be important given the often-opposing roles of ERα and ERβ in breast cancer proliferation and other cellular processes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Pharmacy Publications
 
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Created: Tue, 19 May 2015, 17:09:13 EST by Mr Meng-wong Taing on behalf of School of Pharmacy