E-cadherin junctions as active mechanical integrators in tissue dynamics

Lecuit, Thomas and Yap, Alpha S. (2015) E-cadherin junctions as active mechanical integrators in tissue dynamics. Nature Cell Biology, 17 5: 533-539. doi:10.1038/ncb3136


Author Lecuit, Thomas
Yap, Alpha S.
Title E-cadherin junctions as active mechanical integrators in tissue dynamics
Journal name Nature Cell Biology   Check publisher's open access policy
ISSN 1465-7392
1476-4679
Publication date 2015-04-30
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ncb3136
Volume 17
Issue 5
Start page 533
End page 539
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Abstract During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in mechanically coupling the contractile cortices of cells together, thereby distributing the stresses that drive cell rearrangements at both local and tissue levels. Here we discuss the concept that cellular contractility and E-cadherin-based adhesion are functionally integrated by biomechanical feedback pathways that operate on molecular, cellular and tissue scales.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 56 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 62 times in Scopus Article | Citations
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Created: Tue, 19 May 2015, 20:24:12 EST by Susan Allen on behalf of Institute for Molecular Bioscience