Advances in reprogramming to pluripotency

Alateeq, Suad, Fortuna, Patrick R. J. and Wolvetang, Ernst (2015) Advances in reprogramming to pluripotency. Current Stem Cell Research and Therapy, 10 3: 193-207. doi:10.2174/1574888X10666150220154820

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Alateeq, Suad
Fortuna, Patrick R. J.
Wolvetang, Ernst
Title Advances in reprogramming to pluripotency
Journal name Current Stem Cell Research and Therapy   Check publisher's open access policy
ISSN 1574-888X
Publication date 2015-01
Sub-type Article (original research)
DOI 10.2174/1574888X10666150220154820
Open Access Status Not yet assessed
Volume 10
Issue 3
Start page 193
End page 207
Total pages 15
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2016
Language eng
Abstract Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. Various approaches for PSC derivation from somatic cells have been reported in the literature. The method used for reprogramming is particularly relevant as it may affect the characteristics and quality of PSCs. This review will present an overview of the basic strategies and methods for reprogramming to pluripotency. These strategies will be briefly discussed in the context of how the mechanism of reprogramming could influence PSC characteristics with respect to safety and quality. Aspects of the reprogramming approach that can influence PSC properties, such as culture conditions and donor cell source, are also discussed.
Keyword iPSCs
Nuclear reprogramming
Pluripotent stem cells
Reprogramming strategies
Reprogramming technology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 17 May 2015, 01:45:19 EST by System User on behalf of Scholarly Communication and Digitisation Service