Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

Fall, Tove, Hagg, Sara, Ploner, Alexander, Maegi, Reedik, Fischer, Krista, Draisma, Harmen H. M., Sarin, Antti-Pekka, Benyamin, Beben, Ladenvall, Claes, Akerlund, Mikael, Kals, Mart, Esko, Tonu, Nelson, Christopher P., Kaakinen, Marika, Huikari, Ville, Mangino, Massimo, Meirhaeghe, Aline, Kristiansson, Kati, Nuotio, Marja-Liisa, Kobl, Michael, Grallert, Harald, Dehghan, Abbas, Kuningas, Maris, de Vries, Paul S., de Bruijn, Renee F. A. G., Willems, Sara M., Heikkila, Kauko, Silventoinen, Karri, Pietilainen, Kirsi H., Legry, Vanessa, Giedraitis, Vilmantas, Goumidi, Louisa, Syvanen, Ann-Christine, Strauch, Konstantin, Koenig, Wolfgang, Lichtner, Peter, Herder, Christian, Palotie, Aarno, Menni, Cristina, Uitterlinden, Andre G., Kuulasmaa, Kari, Havulinna, Aki S., Moreno, Luis A., Gonzalez-Gross, Marcela, Evans, Alun, Tregouet, David-Alexandre, Yarnell, John W. G., Virtamo, Jarmo, Ferrieres, Jean, Veronesi, Giovanni, Perola, Markus, Arveiler, Dominique, Brambilla, Paolo, Lind, Lars, Kaprio, Jaakko, Hofman, Albert, Stricker, Bruno H., van Duijn, Cornelia M., Ikram, M. Arfan, Franco, Oscar H., Cottel, Dominique, Dallongeville, Jean, Hall, Alistair S., Jula, Antti, Tobin, Martin D., Penninx, Brenda W., Peters, Annette, Gieger, Christian, Samani, Nilesh J., Montgomery, Grant W., Whiteld, John B., Martin, Nicholas G., Groop, Leif, Spector, Tim D., Magnusson, Patrik K., Amouyel, Philippe, Boomsma, Dorret I., Nilsson, Peter M., Jarvelin, Marjo-Riitta, Lyssenko, Valeriya, Metspalu, Andres, Strachan, David P., Salomaa, Veikko, Ripatti, Samuli, Pedersen, Nancy L., Prokopenko, Inga, McCarthy, Mark I. and Ingelsson, Erik (2015) Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Diabetes, 64 5: 1841-1852. doi:10.2337/db14-0988

Author Fall, Tove
Hagg, Sara
Ploner, Alexander
Maegi, Reedik
Fischer, Krista
Draisma, Harmen H. M.
Sarin, Antti-Pekka
Benyamin, Beben
Ladenvall, Claes
Akerlund, Mikael
Kals, Mart
Esko, Tonu
Nelson, Christopher P.
Kaakinen, Marika
Huikari, Ville
Mangino, Massimo
Meirhaeghe, Aline
Kristiansson, Kati
Nuotio, Marja-Liisa
Kobl, Michael
Grallert, Harald
Dehghan, Abbas
Kuningas, Maris
de Vries, Paul S.
de Bruijn, Renee F. A. G.
Willems, Sara M.
Heikkila, Kauko
Silventoinen, Karri
Pietilainen, Kirsi H.
Legry, Vanessa
Giedraitis, Vilmantas
Goumidi, Louisa
Syvanen, Ann-Christine
Strauch, Konstantin
Koenig, Wolfgang
Lichtner, Peter
Herder, Christian
Palotie, Aarno
Menni, Cristina
Uitterlinden, Andre G.
Kuulasmaa, Kari
Havulinna, Aki S.
Moreno, Luis A.
Gonzalez-Gross, Marcela
Evans, Alun
Tregouet, David-Alexandre
Yarnell, John W. G.
Virtamo, Jarmo
Ferrieres, Jean
Veronesi, Giovanni
Perola, Markus
Arveiler, Dominique
Brambilla, Paolo
Lind, Lars
Kaprio, Jaakko
Hofman, Albert
Stricker, Bruno H.
van Duijn, Cornelia M.
Ikram, M. Arfan
Franco, Oscar H.
Cottel, Dominique
Dallongeville, Jean
Hall, Alistair S.
Jula, Antti
Tobin, Martin D.
Penninx, Brenda W.
Peters, Annette
Gieger, Christian
Samani, Nilesh J.
Montgomery, Grant W.
Whiteld, John B.
Martin, Nicholas G.
Groop, Leif
Spector, Tim D.
Magnusson, Patrik K.
Amouyel, Philippe
Boomsma, Dorret I.
Nilsson, Peter M.
Jarvelin, Marjo-Riitta
Lyssenko, Valeriya
Metspalu, Andres
Strachan, David P.
Salomaa, Veikko
Ripatti, Samuli
Pedersen, Nancy L.
Prokopenko, Inga
McCarthy, Mark I.
Ingelsson, Erik
Title Age- and sex-specific causal effects of adiposity on cardiovascular risk factors
Journal name Diabetes   Check publisher's open access policy
ISSN 0012-1797
Publication date 2015-05
Sub-type Article (original research)
DOI 10.2337/db14-0988
Open Access Status Not yet assessed
Volume 64
Issue 5
Start page 1841
End page 1852
Total pages 12
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Collection year 2016
Language eng
Formatted abstract
Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10−107) and stratified analyses (all P < 3.3 × 10−30). We found evidence of a causal effect of adiposity on blood pressure, fasting levels of insulin, C-reactive protein, interleukin-6, HDL cholesterol, and triglycerides in a nonstratified analysis and in the <55-year stratum. Further, we found evidence of a smaller causal effect on total cholesterol (P for difference = 0.015) in the ≥55-year stratum than in the <55-year stratum, a finding that could be explained by biology, survival bias, or differential medication. In conclusion, this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.
Keyword Body mass index (BMI)
C reactive protein
Insulin resistance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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