Current trends in the etiology and diagnosis of HPV-related head and neck cancers

Chai, Ryan C., Lambie, Duncan, Verma, Mukesh and Punyadeera, Chamindie (2015) Current trends in the etiology and diagnosis of HPV-related head and neck cancers. Cancer Medicine, 4 4: 596-607. doi:10.1002/cam4.424


Author Chai, Ryan C.
Lambie, Duncan
Verma, Mukesh
Punyadeera, Chamindie
Title Current trends in the etiology and diagnosis of HPV-related head and neck cancers
Journal name Cancer Medicine   Check publisher's open access policy
ISSN 2045-7634
Publication date 2015-04
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/cam4.424
Open Access Status DOI
Volume 4
Issue 4
Start page 596
End page 607
Total pages 12
Place of publication Bognor Regis, West Sussex, United Kingdom
Publisher John Wiley and Sons
Collection year 2016
Language eng
Formatted abstract
Human papilloma virus (HPV) infection is a major risk factor for a distinct subset of head and neck squamous cell carcinoma (HNSCC). The current review summarizes the epidemiology of HNSCC and the disease burden, the infectious cycle of HPV, the roles of viral oncoproteins, E6 and E7, and the downstream cellular events that lead to malignant transformation. Current techniques for the clinical diagnosis of HPV-associated HNSCC will also be discussed, that is, the detection of HPV DNA, RNA, and the HPV surrogate marker, p16 in tumor tissues, as well as HPV-specific antibodies in serum. Such methods do not allow for the early detection of HPV-associated HNSCC and most cases are at an advanced stage upon diagnosis. Novel noninvasive approaches using oral fluid, a clinically relevant biological fluid, allow for the detection of HPV and cellular alterations in infected cells, which may aid in the early detection and HPV-typing of HNSCC tumors. Noninvasive diagnostic methods will enable early detection and intervention, leading to a significant reduction in mortality and morbidity associated with HNSCC.
Keyword Biomarkers
Epidemiology
Hpv
Oropharyngeal Cancer
Saliva diagnostics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
 
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